Title:
ACUTE RESPIRATORY DISTRESS SYNDROME THERAPEUTIC AGENT
Document Type and Number:
WIPO Patent Application WO/2017/073255
Kind Code:
A1
Abstract:
Provided is an acute respiratory distress syndrome therapeutic agent whose active ingredient is lecithinated superoxide dismutase represented by general formula (I): SOD'(Q-B)m (I) (in the formula, SOD' is a superoxide dismutase residue, Q is chemical crosslinking, B is a residue obtained by removing the hydrogen atom of the hydroxyl group in lysolecithin having a hydroxyl group at position 2 of the glycerol, and m is the average number of bonds of lysolecithin per 1 molecule of superoxide dismutase and is an integer of 1 or greater).
Inventors:
MIZUSHIMA TORU (JP)
Application Number:
PCT/JP2016/079399
Publication Date:
May 04, 2017
Filing Date:
October 04, 2016
Export Citation:
Assignee:
LTT BIO-PHARMA CO LTD (JP)
International Classes:
A61K38/44; A61K47/26; A61P11/00
Domestic Patent References:
| WO2010064522A1 | 2010-06-10 | |||
| WO2008075706A1 | 2008-06-26 |
Foreign References:
| JP2001064199A | 2001-03-13 | |||
| JP2010215527A | 2010-09-30 |
Other References:
YUJI FUJINO ET AL.: "Assessment of bleomycin- induced pulmonary fibrosis by broncholaveolar lavage", THE JAPANESE JOURNAL OF THORACIC DISEASES, vol. 27, no. 2, 1989, pages 180 - 187, XP003032446, ISSN: 0301-1542
JOHO TOKUMINE ET AL.: "Kotsuzui Kansaibo Inyu ni yoru Hai Shogai Shufuku Sokushin no Kokoromi", RESPIRATORY MOLECULAR MEDICINE, vol. 10, no. 3, 2006, pages 209 - 211, XP009510914, ISSN: 1342-436X
MATUTE-BELLO G ET AL.: "Animal models of acute lung injury", AMERICAN JOURNAL OF PHYSIOLOGY. LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, vol. 295, no. 3, pages L379 - L399, XP055380574, ISSN: 1040-0605
YEN CC ET AL.: "Aerosolized human extracellular superoxide dismutase prevents hyperoxia-induced lung injury", PLOS ONE, vol. 6, no. 10, 26 October 2011 (2011-10-26), pages e26870, XP055380577, ISSN: 1932-6203
LIU H ET AL.: "Superoxide anion, the main species of ROS in the development of ARDS induced by oleic acid", FREE RADICAL RESEARCH, vol. 38, no. 12, December 2004 (2004-12-01), pages 1281 - 1287, XP055380579, ISSN: 1071-5762
KOYAMA S ET AL.: "Recombinant-human superoxide dismutase attenuates endotoxin-induced lung injury in awake sheep", AMERICAN REVIEW OF RESPIRATORY DISEASE, vol. 145, no. 6, 1992, pages 1404 - 1409, XP009510528, ISSN: 0003-0805
TORU MIZUSHIMA: "Development of Lecithinized Superoxide Dismutase as a Drug for IPF", DRUG DELIVERY SYSTEM, vol. 28, no. 3, 2013, pages 221 - 228, XP055380584, ISSN: 0913-5006
TORU MIZUSHIMA: "Lecithinized SOD no Rinsho Oyo", RESPIRATORY MOLECULAR MEDICINE, vol. 16, no. 1, 2012, pages 88 - 90, XP009510837, ISSN: 1342-436X
TORU MIZUSHIMA: "Development of Lecithinized Superoxide Dismutase as a Drug for IPF", JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, vol. 134, no. 1, 2014, pages 69 - 76, XP003032447, ISSN: 0031-6903
MASARU ANDO, OSAMU ONIZUKA, MASAYA KAWANO, KAZUNOBU ITO, EIJI MIYAZAKI, TOMIYASU TSUDA: "Lecithinized SOD no LPS Jakki Kyusei Hai Shogai ni Taisuru Keigen Koka ni Tsuite no Kento [Pulmonary and Endobronchial Tuberculosis with Subclavian Artery-Pulmonary Artery Shunts]", THE JAPANESE JOURNAL OF THORACIC DISEASES, vol. 34, no. 3, 25 March 1996 (1996-03-25), pages 374 - 379, XP009510912, ISSN: 0301-1542, DOI: 10.11389/jjrs1963.34.374
HIROSHI YAMADA ET AL.: "Jikken Koza ARDS Model Sakuseiho", SURGERY FRONTIER, vol. 10, no. 3, 2003, pages 295 - 299, XP009510913, ISSN: 1340-5594
See also references of EP 3369430A4
JOHO TOKUMINE ET AL.: "Kotsuzui Kansaibo Inyu ni yoru Hai Shogai Shufuku Sokushin no Kokoromi", RESPIRATORY MOLECULAR MEDICINE, vol. 10, no. 3, 2006, pages 209 - 211, XP009510914, ISSN: 1342-436X
MATUTE-BELLO G ET AL.: "Animal models of acute lung injury", AMERICAN JOURNAL OF PHYSIOLOGY. LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, vol. 295, no. 3, pages L379 - L399, XP055380574, ISSN: 1040-0605
YEN CC ET AL.: "Aerosolized human extracellular superoxide dismutase prevents hyperoxia-induced lung injury", PLOS ONE, vol. 6, no. 10, 26 October 2011 (2011-10-26), pages e26870, XP055380577, ISSN: 1932-6203
LIU H ET AL.: "Superoxide anion, the main species of ROS in the development of ARDS induced by oleic acid", FREE RADICAL RESEARCH, vol. 38, no. 12, December 2004 (2004-12-01), pages 1281 - 1287, XP055380579, ISSN: 1071-5762
KOYAMA S ET AL.: "Recombinant-human superoxide dismutase attenuates endotoxin-induced lung injury in awake sheep", AMERICAN REVIEW OF RESPIRATORY DISEASE, vol. 145, no. 6, 1992, pages 1404 - 1409, XP009510528, ISSN: 0003-0805
TORU MIZUSHIMA: "Development of Lecithinized Superoxide Dismutase as a Drug for IPF", DRUG DELIVERY SYSTEM, vol. 28, no. 3, 2013, pages 221 - 228, XP055380584, ISSN: 0913-5006
TORU MIZUSHIMA: "Lecithinized SOD no Rinsho Oyo", RESPIRATORY MOLECULAR MEDICINE, vol. 16, no. 1, 2012, pages 88 - 90, XP009510837, ISSN: 1342-436X
TORU MIZUSHIMA: "Development of Lecithinized Superoxide Dismutase as a Drug for IPF", JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, vol. 134, no. 1, 2014, pages 69 - 76, XP003032447, ISSN: 0031-6903
MASARU ANDO, OSAMU ONIZUKA, MASAYA KAWANO, KAZUNOBU ITO, EIJI MIYAZAKI, TOMIYASU TSUDA: "Lecithinized SOD no LPS Jakki Kyusei Hai Shogai ni Taisuru Keigen Koka ni Tsuite no Kento [Pulmonary and Endobronchial Tuberculosis with Subclavian Artery-Pulmonary Artery Shunts]", THE JAPANESE JOURNAL OF THORACIC DISEASES, vol. 34, no. 3, 25 March 1996 (1996-03-25), pages 374 - 379, XP009510912, ISSN: 0301-1542, DOI: 10.11389/jjrs1963.34.374
HIROSHI YAMADA ET AL.: "Jikken Koza ARDS Model Sakuseiho", SURGERY FRONTIER, vol. 10, no. 3, 2003, pages 295 - 299, XP009510913, ISSN: 1340-5594
See also references of EP 3369430A4
Attorney, Agent or Firm:
KUSAMA, Osamu (JP)
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