Title:
ACYL SULFAMIDES FOR TREATMENT OF OBESITY, DIABETES AND LIPID DISORDERS
Document Type and Number:
WIPO Patent Application WO2002060388
Kind Code:
A3
Abstract:
A class of acyl sulfamides comprises compounds that are potent ligands for PPAR gamma and generally have antagonist or partial agonist activity. The compounds may be useful in the treatment, control or prevention of obesity, non-insulin dependent diabetes mellitus (NIDDM), hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, atherosclerosis, vascular restenosis, inflammation, and other PPAR gamma mediated diseases, disorders and conditions.
Inventors:
JONES A BRIAN (US)
ACTON JOHN J III (US)
ACTON JOHN J III (US)
Application Number:
PCT/US2002/003119
Publication Date:
February 27, 2003
Filing Date:
January 25, 2002
Export Citation:
Assignee:
MERCK & CO INC (US)
JONES A BRIAN (US)
ACTON JOHN J III (US)
JONES A BRIAN (US)
ACTON JOHN J III (US)
International Classes:
A61K31/18; A61K31/222; A61K31/235; A61K31/27; A61P1/04; A61P1/18; A61P3/04; A61P3/06; A61P3/10; A61P5/28; A61P5/50; A61P9/00; A61P9/10; A61P9/12; A61K45/00; A61P15/00; A61P17/00; A61P17/06; A61P17/10; A61P25/00; A61P25/28; A61P27/02; A61P29/00; A61P35/00; A61P43/00; C07C335/26; C07C381/08; C07D211/26; F16M11/00; F24H9/06; (IPC1-7): A61K31/16; A61K31/17; A61K31/22; A61K31/24; A61K31/27; A61K31/445; C07C67/02; C07C69/76; C07C271/12; C07C271/28; C07C275/24; C07C275/28; C07C381/10; C07D211/60
Foreign References:
| US5336690A | 1994-08-09 |
Other References:
See also references of EP 1357908A4
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