Title:
ADMINISTRATION OF A THIOL-BASED CHEMOPROTECTANT COMPOUND
Document Type and Number:
WIPO Patent Application WO2001080832
Kind Code:
A3
Abstract:
A method of administration of a thiol-based chemoprotectant agent including NAC (N-acetylcysteine) and STS (sodium thiosulfate) that markedly affects biodistribution and protects against injury from diagnostic or therapeutic intra-arterial procedures. A method for treating or mitigating the side effects of cytotoxic cancer therapy for tumors located in the head or neck and brain tumors. The thiol-based chemoprotectant agent is administered intra-arterially with rapid and first pass uptake in organs and tissues other than the liver.
Inventors:
PAGEL MICHAEL A (US)
MULDOON LESLIE (US)
NEUWELT EDWARD A (US)
MULDOON LESLIE (US)
NEUWELT EDWARD A (US)
Application Number:
PCT/US2001/040624
Publication Date:
May 15, 2003
Filing Date:
April 26, 2001
Export Citation:
Assignee:
UNIV OREGON HEALTH SCIENCES (US)
US GOV VETERANS AFFAIRS (US)
PAGEL MICHAEL A (US)
MULDOON LESLIE (US)
NEUWELT EDWARD A (US)
US GOV VETERANS AFFAIRS (US)
PAGEL MICHAEL A (US)
MULDOON LESLIE (US)
NEUWELT EDWARD A (US)
International Classes:
A61K9/08; A61K31/095; A61K31/195; A61K31/198; A61K31/337; A61K31/661; A61K33/04; A61K33/243; A61K38/05; A61K38/06; A61K45/00; A61K47/06; A61P35/00; A61P43/00; (IPC1-7): A61K9/08; A61K31/195; A61K38/06; A61K31/66
Domestic Patent References:
| WO1994000141A1 | 1994-01-06 | |||
| WO1999029312A1 | 1999-06-17 | |||
| WO1996026643A1 | 1996-09-06 | |||
| WO1998034622A1 | 1998-08-13 | |||
| WO1994003179A1 | 1994-02-17 |
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