Title:
PREVENTION/TREATMENT AGENT FOR DIABETIC RETINOPATHY AND FOODSTUFF AIMING TO PREVENT/TREAT DIABETIC RETINOPATHY, AMELIORATING AGENT FOR VARIOUS SYMPTOMS OF DIABETIC RETINOPATHY AND FOODSTUFF AIMING TO AMELIORATE VARIOUS SYMPTOMS OF DIABETIC RETINOPATHY, AND METHOD FOR DETERMINING DOSING PERIOD OF PREVENTION/AMELIORATING AGENT FOR DIABETIC RETINOPATHY
Document Type and Number:
WIPO Patent Application WO/2011/089951
Kind Code:
A1
Abstract:
Disclosed are a prevention/treatment agent for diabetic retinopathy characterized by containing lutein; said prevention/treatment agent, an ameliorating agent for an electroretinogram, an apoptosis suppression agent for retinal ganglion cells, a decrease suppression agent for molecules related to neural transmission, an ERK activation suppression agent, or a decrease suppression agent for brain-derived neurotrophic factors for being administered in the initial stage of diabetic retinopathy including simple retinopathy or preproliferative retinopathy; and a method for determining the dosing period of a prevention/ameliorating agent for diabetic retinopathy by means of comparing measured electroretinogram values with normal measured electroretinogram values, or by means of observing changes in the thicknesses of the inner plexiform layer, the inner granular layer, and the ganglion cell layer of the retina using optical coherence tomography.
Inventors:
TSUBOTA KAZUO (JP)
OZAWA YOKO (JP)
SASAKI MARIKO (JP)
KOBAYASHI SAORI (JP)
OZAWA YOKO (JP)
SASAKI MARIKO (JP)
KOBAYASHI SAORI (JP)
Application Number:
PCT/JP2011/050291
Publication Date:
July 28, 2011
Filing Date:
January 11, 2011
Export Citation:
Assignee:
UNIV KEIO (JP)
WAKASA HOLDINGS CO LTD (JP)
TSUBOTA KAZUO (JP)
OZAWA YOKO (JP)
SASAKI MARIKO (JP)
KOBAYASHI SAORI (JP)
WAKASA HOLDINGS CO LTD (JP)
TSUBOTA KAZUO (JP)
OZAWA YOKO (JP)
SASAKI MARIKO (JP)
KOBAYASHI SAORI (JP)
International Classes:
A61K31/047; A61P27/02; A61P39/06; A61P43/00
Foreign References:
| US20060205826A1 | 2006-09-14 |
Other References:
ARNAL, E. ET AL.: "Beneficial effect of docosahexanoic acid and lutein on retinal structural, metabolic, and functional abnormalities in diabetic rats", CURR EYE RES, vol. 34, no. LL, 2009, pages 928 - 38
MIRANDA, M. ET AL.: "Oxidative stress in a model of experimental diabetic retinopathy: the utility of peroxinytrite scavengers", ARCH SOC ESP OFTALMOL, vol. 81, no. 1, 2006, pages 27 - 32
MIRANDA, M. ET AL.: "Oxidative stress in a model for experimental diabetic retinopathy: treatment with antioxidants", ARCH SOC ESP OFTALMOL, vol. 79, no. 6, 2004, pages 289 - 94
LI, S.Y. ET AL.: "Effect of lutein on retinal neurons and oxidative stress in a model of acute retinal ischemia/reperfusion", INVEST OPHTHALMOL VIS SCI, vol. 50, no. 2, 2009, pages 836 - 43
AKIHIRO KAKEHASHI: "Tonyobyo Momakusho no Rikai no Shinpo -Gankai kara Naikai e", MEDICAL PRACTICE, vol. 20, no. 5, 2003, pages 781 - 786
MIRANDA, M. ET AL.: "Oxidative stress in a model of experimental diabetic retinopathy: the utility of peroxinytrite scavengers", ARCH SOC ESP OFTALMOL, vol. 81, no. 1, 2006, pages 27 - 32
MIRANDA, M. ET AL.: "Oxidative stress in a model for experimental diabetic retinopathy: treatment with antioxidants", ARCH SOC ESP OFTALMOL, vol. 79, no. 6, 2004, pages 289 - 94
LI, S.Y. ET AL.: "Effect of lutein on retinal neurons and oxidative stress in a model of acute retinal ischemia/reperfusion", INVEST OPHTHALMOL VIS SCI, vol. 50, no. 2, 2009, pages 836 - 43
AKIHIRO KAKEHASHI: "Tonyobyo Momakusho no Rikai no Shinpo -Gankai kara Naikai e", MEDICAL PRACTICE, vol. 20, no. 5, 2003, pages 781 - 786
Attorney, Agent or Firm:
Kyoto International Patent Law Office (JP)
Patent business corporation Kyoto international patent firm (JP)
Patent business corporation Kyoto international patent firm (JP)
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