Title:
PROPHYLACTIC/THERAPEUTIC AGENT FOR VIRUS INFECTIONS WHICH COMPRISES ALA COMPOUND
Document Type and Number:
WIPO Patent Application WO/2016/163082
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a prophylactic/therapeutic agent which is inexpensive, has little adverse side effects and is effective against long-term persistent virus infections. A 5-aminolevulinic acid compound represented by formula (I) (wherein R1 represents a hydrogen atom or an acyl group; and R2 represents a hydrogen atom, a linear or branched alkyl group, a cycloalkyl group, an aryl group or an aralkyl group) or a salt thereof can be used as a prophylactic/therapeutic agent for virus infections, and can prevent proliferation of viruses.
Inventors:
TANAKA TOHRU (JP)
NAKAJIMA MOTOWO (JP)
HARA TAKESHI (JP)
NAKAJIMA MOTOWO (JP)
HARA TAKESHI (JP)
Application Number:
PCT/JP2016/001609
Publication Date:
October 13, 2016
Filing Date:
March 18, 2016
Export Citation:
Assignee:
SBI PHARMACEUTICALS CO LTD (JP)
International Classes:
A61K31/197; A61K31/295; A61K31/555; A61K33/26; A61K38/16; A61P31/12; A61P31/14; A61P31/20; A61P43/00
Domestic Patent References:
| WO2014013664A1 | 2014-01-23 |
Foreign References:
| JP2000510123A | 2000-08-08 |
Other References:
NISHIO, Y. ET AL.: "5-Aminolevulinic acid combined with ferrous iron enhances the expression of heme oxygenase-1", INT. IMMUNOPHARMACOL., vol. 19, no. 2, 2014, pages 300 - 307, XP028633725, ISSN: 1567-5769
PROTZER, U. ET AL.: "Antiviral activity and hepatoprotection by heme oxygenase-1 in hepatitis B virus infection", GASTROENTEROLOGY, vol. 133, no. 4, 2007, pages 1156 - 1165, XP022271806, ISSN: 0016-5085
SCHMIDT, W.N. ET AL.: "Heme and HO-1 Inhibition of HCV, HBV, and HIV", FRONT. PHARMACOL., vol. 3, 2012, XP055319520, ISSN: 1663-9812
HILL-BATORSKI, L. ET AL.: "The cytoprotective enzyme heme oxygenase-1 suppresses Ebola virus replication", J. VIROL., vol. 87, no. 24, 2013, pages 13795 - 13802, XP055319525, ISSN: 0022-538X
PROTZER, U. ET AL.: "Antiviral activity and hepatoprotection by heme oxygenase-1 in hepatitis B virus infection", GASTROENTEROLOGY, vol. 133, no. 4, 2007, pages 1156 - 1165, XP022271806, ISSN: 0016-5085
SCHMIDT, W.N. ET AL.: "Heme and HO-1 Inhibition of HCV, HBV, and HIV", FRONT. PHARMACOL., vol. 3, 2012, XP055319520, ISSN: 1663-9812
HILL-BATORSKI, L. ET AL.: "The cytoprotective enzyme heme oxygenase-1 suppresses Ebola virus replication", J. VIROL., vol. 87, no. 24, 2013, pages 13795 - 13802, XP055319525, ISSN: 0022-538X
Attorney, Agent or Firm:
HIROTA, Masanori (JP)
Masaki Hirota (JP)
Masaki Hirota (JP)
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