Title:
AGONIST POLYPEPTIDE OF RECEPTOR FOR ZOT AND ZONULIN
Document Type and Number:
WIPO Patent Application WO2005010022
Kind Code:
A3
Abstract:
Agonist polypeptide of a receptor protein has been identified. The agonist can be used to facilitate drug and antigen absorption. Suitable routes of administration include oral, nasal, transdermal, and intravenous. Pharmaceutical formulations may comprise a therapeutic agent or an immunogenic agent in combination with the agonist polypeptide.
Inventors:
FASANO ALESSIO (US)
VOGEL STEFANIE N (US)
VOGEL STEFANIE N (US)
Application Number:
PCT/US2004/022753
Publication Date:
July 06, 2006
Filing Date:
July 15, 2004
Export Citation:
Assignee:
UNIV MARYLAND (US)
FASANO ALESSIO (US)
VOGEL STEFANIE N (US)
FASANO ALESSIO (US)
VOGEL STEFANIE N (US)
International Classes:
C07K5/00; A61K38/08; A61K38/10; B65H23/188; C07K14/28; C07K
Other References:
WANG ET AL.: "Human zonulin, a potential modulator of intestinal tight junctions", J. CELL SCI., vol. 113, no. PT 24, December 2000 (2000-12-01), pages 4435 - 4440, XP002201099
FASANO A.: "Modulation of intestinal permeability: an innovative method of oral drug delivery for the treatment of inherited and acquired human diseases", MOL. GENET. METAB., vol. 64, no. 1, May 1998 (1998-05-01), pages 12 - 18, XP003001707
FASANO A.: "Modulation of intestinal permeability: an innovative method of oral drug delivery for the treatment of inherited and acquired human diseases", MOL. GENET. METAB., vol. 64, no. 1, May 1998 (1998-05-01), pages 12 - 18, XP003001707
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