Title:
ALPHA-ENOLASE SPECIFIC ANTIBODIES AND METHOD OF USE IN IMMUNE DISEASES
Document Type and Number:
WIPO Patent Application WO/2015/095863
Kind Code:
A3
Abstract:
A method for treating an inflammatory disease or an immune disorder includes administering to a subject in need of such treatment an antagonist against ENO1. The antagonist binds ENO1 and inhibits ENO1 plasminogen receptor activity. The antagonist may be an anti-human ENO1 antibody, or an scFv, Fab, or F(ab)2 fragment thereof, that specifically binds to human ENO1 (GenBank: AAH50642.1) for the treatment of an inflammatory disease or an immune disorder, which may be multiple sclerosis, rheumatoid arthritis, Crohn's disease, ulcerative colitis, systemic Lupus erythematosus, chronic obstructive pulmonary disease (COPD), asthma, allergy, psoriasis, type 1 diabetes mellitus, artherosclerosis or osteoporosis.
Inventors:
TSAI SHIH-CHONG (TW)
CHANG MINGL (TW)
YUAN TA-TUNG (TW)
TSENG SHIH-CHI (TW)
CHEN SHYI-JOU (TW)
CHIA WEI-TSO (TW)
WANG HSIN-YUN (TW)
CHANG MINGL (TW)
YUAN TA-TUNG (TW)
TSENG SHIH-CHI (TW)
CHEN SHYI-JOU (TW)
CHIA WEI-TSO (TW)
WANG HSIN-YUN (TW)
Application Number:
PCT/US2014/071844
Publication Date:
November 12, 2015
Filing Date:
December 22, 2014
Export Citation:
Assignee:
DEV CENTER BIOTECHNOLOGY
DCB USA LLC (US)
DCB USA LLC (US)
International Classes:
A61K39/395; C07K16/00
Foreign References:
| US20110182907A1 | 2011-07-28 | |||
| US20070172487A1 | 2007-07-26 | |||
| US20070077583A1 | 2007-04-05 |
Other References:
WYGRECKA ET AL.: "Enolase-1 promotes plasminogen-mediated recruitment of monocytes to the acutely inflamed lung.", BLOOD., vol. 113, no. 22, 2009, pages 5588 - 98, XP055237205, ISSN: 0006-4971
DIAZ-RAMOS. ET AL.: "Alpha-Enolase, a Multifunctional Protein: Its Role on Pathophysiological Situations.", J BIOMED BIOTECHNOL., vol. 179, no. 5, 2012, pages 1 - 13., XP055203639, ISSN: 1110-7243
DIAZ-RAMOS. ET AL.: "Alpha-Enolase, a Multifunctional Protein: Its Role on Pathophysiological Situations.", J BIOMED BIOTECHNOL., vol. 179, no. 5, 2012, pages 1 - 13., XP055203639, ISSN: 1110-7243
Attorney, Agent or Firm:
LIANG, T., Chyau et al. (909 Fannin StreetSuite 350, Houston TX, US)
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