ALPHA-HYDROXY, -AMINO AND -FLUORO DERIVATIVES OF BETA-SULPHONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASES INHIBITORS

Title:

ALPHA-HYDROXY, -AMINO AND -FLUORO DERIVATIVES OF BETA-SULPHONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASES INHIBITORS

Document Type and Number:

WIPO Patent Application WO1999026909

Kind Code:

A3

Abstract:

The present invention provides a compound of formula (I), or pharmaceutical acceptable salts thereof wherein R1 is C4-12 alkyl, C4-12 alkenyl, C4-12 alkynyl, -(CH2)h-C3-8 cycloalkyl, substituted and unsubstituted -(CH2)h-aryl, substituted and unsubstituted-(CH2)h-het, R2 is substituted and unsubstituted C1-12 alkyl, substituted and unsubstituted C2-12 alkenyl, substituted and unsubstituted C2-12 alkynyl, substituted and unsubstituted-(CH2)h-C3-8 cycloakyl, substituted and unsubstituted -(CH2)h-C3-8 cycloalkenyl, substituted and unsubstituted -(CH2)h-aryl, substituted and unsubstituted -(CH2)h-heterocyclic ring, substituted and unsubstituted -(CH2)i-X-R4 (X is -O-, -S(=O)j-, -NR7-, -S(=O)2NR8-, or -C(=O)-), and -(CH2)iCHR5R6. The compounds are inhibitors of matrix metalloproteinases involved in tissue degradation.

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Inventors:

WARPEHOSKI MARTHA A (US)
MITCHELL MARK ALLEN (US)
HARPER DONALD E (US)
MAGGIORA LINDA LOUISE (US)

Application Number:

PCT/IB1998/002154

Publication Date:

August 26, 1999

Filing Date:

November 18, 1998

Export Citation:

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Assignee:

UPJOHN CO (US)
WARPEHOSKI MARTHA A (US)
MITCHELL MARK ALLEN (US)
HARPER DONALD E (US)
MAGGIORA LINDA LOUISE (US)

International Classes:

A61K31/16; A61K31/165; A61K31/41; A61K31/4164; C07D253/06; A61K31/4166; A61K31/42; A61K31/426; A61K31/433; A61K31/4402; A61K31/4409; A61K31/4418; A61K31/4427; A61K31/4439; A61K31/496; A61K31/5025; A61K31/53; A61P1/02; A61P1/04; A61P11/06; A61P13/00; A61P13/10; A61P17/02; A61P29/00; A61P35/04; A61P43/00; C07C317/46; C07C317/50; C07D213/52; C07D213/68; C07D213/70; C07D233/64; C07D233/74; C07D233/84; C07D257/04; C07D261/08; C07D277/20; C07D277/40; C07D285/12; C07D401/12; C07D487/04; (IPC1-7): C07C317/44; C07C317/46; C07C317/48; A61K31/19

Domestic Patent References:

WO1998013340A1	1998-04-02
WO1998039326A1	1998-09-11

Foreign References:

EP0780386A1

1997-06-25

Other References:

CHEMICAL ABSTRACTS, vol. 119, no. 23, 6 December 1993, Columbus, Ohio, US; abstract no. 240883, BOYLE, G. W. ET AL: "Metabolism of Casodex in laboratory animals" XP002105163
CHEMICAL ABSTRACTS, vol. 108, no. 17, 25 April 1988, Columbus, Ohio, US; abstract no. 150945, GRIFFITH, OWEN W.: "Amino acid sulfones: S-benzyl-DL-.alpha.-methylcysteine sulfone" XP002105164

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