Title:
ALPHA-METHYLBENZYL-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A PHENYLENEDIAMINE GROUP
Document Type and Number:
WIPO Patent Application WO2000034260
Kind Code:
A3
Abstract:
Compounds having formula (I) wherein R1-R5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon members, aryl, heteroaryl, halogen,-CN,-NO2,-CO2R6,-COR6,-OR6,-SR6,-SOR6,-SO2R6,-CONR7R8,-NR6N(R7R8),-N(R7R8) or W-Y-(CH2)n-Z provided that at least one of R1-R5 is not hydrogen; or R2 and R3, or R3 and R4, taken together to form a 3 to 7 membered heterocycloalkyl or 3 to 7 membered heteroaryl; R6 and R7 are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; R8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, or R7 and R8, taken together may form a 3 to 7 membered heterocycloalkyl; W is O, NR6, or is absent; Y is -(CO)- or-(CO2)-, or is absent; Z is alkyl of 1 to 4 carbon atoms,-CN,-CO2R6, COR6,-CONR7R8,-OCOR6,-NR6COR7,-OCONR6,-OR6,-SR6,-SOR6,-SO2R6, SR6N(R7R8),-N(R7R8) or phenyl; G is aryl or fused bicyclic heteroaryl; X is a bond,-NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH)J; J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and n is an integer from 1 to 6; useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and-7, and Kaposi herpesvirus.
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Inventors:
BLOOM JONATHAN DAVID
CURRAN KEVIN JOSEPH
DIGRANDI MARTIN JOSEPH
DUSHIN RUSSELL GEORGE
LANG STANLEY ALBERT
NORTON EMILY BOUCHER
ROSS ADMA ANTONIA
O'HARA BRYAN MARK
CURRAN KEVIN JOSEPH
DIGRANDI MARTIN JOSEPH
DUSHIN RUSSELL GEORGE
LANG STANLEY ALBERT
NORTON EMILY BOUCHER
ROSS ADMA ANTONIA
O'HARA BRYAN MARK
Application Number:
PCT/US1999/028839
Publication Date:
September 08, 2000
Filing Date:
December 06, 1999
Export Citation:
Assignee:
AMERICAN HOME PROD (US)
International Classes:
A61K31/17; A61K31/18; A61K31/343; A61K31/47; A61K31/472; A61K31/4725; A61P31/22; C07C335/20; C07D215/48; C07D215/50; C07D215/54; C07D217/06; C07D217/26; C07D307/79; C07D307/81; C07D307/85; C07D405/12; C07D407/12; (IPC1-7): C07D335/20; C07D285/06; C07D307/68; A61K31/17; A61K31/41; A61K31/34; A61K61/425; A61K31/42; C07D213/81; C07D417/12; C07D263/34; C07D277/56; C07D217/26; A61P31/22
Domestic Patent References:
| WO1997040028A1 | 1997-10-30 | |||
| WO1996025157A1 | 1996-08-22 | |||
| WO1997011052A1 | 1997-03-27 |
Foreign References:
| EP0462933A1 | 1991-12-27 |
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