BIOLOGICALLY ACTIVE 2-R-5-AMINO-1,3,4-THIADIAZOLE DERIVATIVES

WIPO Patent Application WO/2000/034259

A1

The present invention pertains to the field of medicine, more precisely to that of pharmacology, and essentially relates to biologically active synthetic diazoles that consist of 2-R-5-amino-1,3,4-thiadiazole derivatives. These substances are mainly intended for use in medical practice for treating chlamydiae-mediated viral diseases as well as diseases resulting in immunodeficiency, including malignant tumours. The purpose of the present invention is to create new chemical compounds which have a high antiviral and an anti-microbial (anti-chlamydia) activity, which stimulate the production of endogenous interferons in the organism and which also have anti-aggregating, analgesic and psycho-depressive actions. This invention involves synthesising a new group of substances that consist of 2-R-5-amino-1,3,4-thiadiazole derivatives of general formula (1) where R¿1? is selected from the group comprising alkyl, aryl and -CH¿2?-CH¿2?C(0)NH-N=CH-Z, provided that Z is aryl or piperonyl, while R¿2? is selected from the group comprising H and (a), provided that Y is aryl or heteroaryl. This invention further relates to general methods for producing these substances, to 4 examples of the synthesis of said substances, to the identification results of each of the 42 synthesised substances as well as to data concerning the experimental verification of the substance biological activity relative to known preparations used for the same purposes.

WO/1992/022542	AMINOALKYL-SUBSTITUTED 2-AMINO-5-MERCAPTOTHIADIAZOLES, THEIR PREPARATION AND THEIR USE
JP2011513214	11β-Hydroxysteroid dehydrogenase inhibitor

ASHKINAZI RIMMA ILIINICHNA (RU)
KRUTIKOV VIKTOR IOSIFOVICH (RU)

PCT/RU1998/000406

June 15, 2000

December 04, 1998

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ASHKINAZI RIMMA ILIINICHNA (RU)
KRUTIKOV VIKTOR IOSIFOVICH (RU)

C07D285/135; C07D285/12; (IPC1-7): C07D285/135; A61K31/41; A61K31/505; C07D417/12

US3992396A	1976-11-16
GB1482691A	1977-08-10
GB1430386A	1976-03-31
SU845783A3	1981-07-07

CHEMICAL ABSTRACTS, vol. 47, Columbus, Ohio, US; abstract no. 3856C, "alzats <>" column 9323;
CHEMICAL ABSTRACTS, vol. 48, Columbus, Ohio, US; abstract no. 3551F, "alzats f" column 4540;