Title:
AMELIORATING AGENT FOR BLOOD-BRAIN BARRIER DYSFUNCTION
Document Type and Number:
WIPO Patent Application WO/2013/122116
Kind Code:
A1
Abstract:
[Problem] To provide a peptide which can be produced and processed more readily compared with prothymosin α, which is conventionally known, or a peptide thereof and has an activity at a level equivalent to or higher than that of prothymosin α or a peptide thereof.
[Solution] The present invention provides an ameliorating agent for blood-organ barrier dysfunction, a therapeutic agent for diseases associated with blood-organ barrier dysfunction or ischemic diseases or a nerve cell death inhibitor, each comprising, as an active ingredient, a peptide comprising the amino acid sequence represented by SEQ ID NO: 1 or a peptide having substantially the same function as that of the aforementioned peptide.
Inventors:
UEDA HIROSHI (JP)
Application Number:
PCT/JP2013/053436
Publication Date:
August 22, 2013
Filing Date:
February 13, 2013
Export Citation:
Assignee:
UNIV NAGASAKI (JP)
SHIN NIPPON BIOMEDICAL LAB LTD (JP)
SHIN NIPPON BIOMEDICAL LAB LTD (JP)
International Classes:
C07K7/06; A61K38/00; A61K38/08; A61K45/00; A61P1/04; A61P7/02; A61P7/10; A61P9/00; A61P9/10; A61P9/12; A61P27/02; A61P27/06; A61P43/00; C07K14/47
Domestic Patent References:
| WO2011019023A1 | 2011-02-17 | |||
| WO2004064861A1 | 2004-08-05 | |||
| WO2004064861A1 | 2004-08-05 | |||
| WO2011019023A1 | 2011-02-17 |
Other References:
HIROSHI UEDA: "No o Mamoru Tanpakushitsu Prothymosin a Atarashii Nosocchu Chiryoyaku no Kaihatsu ni Mukete", MEDICAL BIO, vol. 5, no. 2, 2008, pages 83 - 89, XP008174720
"New Drug tPA for Cerebral Infarction", CURRENT MEDICAL PRACTICE: MEDICAL PRACTICE: MEDICAL PRACTICE AND NURSING CARE: YOMIURI ONLINE ARTICLE FOR, 25 October 2005 (2005-10-25), Retrieved from the Internet
JOURNAL OF CELL BIOLOGY, vol. 176, 2007, pages 853 - 862
CELL DEATH AND DIFFERENTIATION, vol. 14, 2007, pages 1839 - 1842
CELL DEATH AND DIFFERENTIATION, vol. 16, 2009, pages 349 - 358
SHUNICHI MORIKAWA; TAICHI EZAKI, SEITAI NO KAGAKU, vol. 55, no. 3, 2004, pages 266 - 272
FUJITA ET AL., CELL DEATH AND DIFFER, 2009
J CEREB BLOOD FLOW METAB, vol. 27, no. 4, 2007, pages 697 - 709
J CEREB BLOOD FLOW METAB, vol. 20, no. 12, 2000, pages 1681 - 9
JUNG-KIL LEE ET AL.: "Photochemically induced cerebral ischemia in a mouse model", SURGICAL NEUROLOGY, vol. 67, 2007, pages 620 - 625, XP022079185, DOI: doi:10.1016/j.surneu.2006.08.077
See also references of EP 2816056A4
"New Drug tPA for Cerebral Infarction", CURRENT MEDICAL PRACTICE: MEDICAL PRACTICE: MEDICAL PRACTICE AND NURSING CARE: YOMIURI ONLINE ARTICLE FOR, 25 October 2005 (2005-10-25), Retrieved from the Internet
JOURNAL OF CELL BIOLOGY, vol. 176, 2007, pages 853 - 862
CELL DEATH AND DIFFERENTIATION, vol. 14, 2007, pages 1839 - 1842
CELL DEATH AND DIFFERENTIATION, vol. 16, 2009, pages 349 - 358
SHUNICHI MORIKAWA; TAICHI EZAKI, SEITAI NO KAGAKU, vol. 55, no. 3, 2004, pages 266 - 272
FUJITA ET AL., CELL DEATH AND DIFFER, 2009
J CEREB BLOOD FLOW METAB, vol. 27, no. 4, 2007, pages 697 - 709
J CEREB BLOOD FLOW METAB, vol. 20, no. 12, 2000, pages 1681 - 9
JUNG-KIL LEE ET AL.: "Photochemically induced cerebral ischemia in a mouse model", SURGICAL NEUROLOGY, vol. 67, 2007, pages 620 - 625, XP022079185, DOI: doi:10.1016/j.surneu.2006.08.077
See also references of EP 2816056A4
Attorney, Agent or Firm:
HIROSE TAKAYUKI (JP)
Takayuki Hirose (JP)
Takayuki Hirose (JP)
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Claims: