Title:
AMIDE COMPOUND AND MEDICAL USE THEREOF AS STING INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2021/068950
Kind Code:
A1
Abstract:
Disclosed in the present invention are an amide compound and the medical use thereof as a STING inhibitor. Specifically, disclosed is a compound represented by formula I or formula II, or a pharmaceutically acceptable salt or ester or solvate thereof, which can be used for preparing a STING inhibitor or a drug capable of inhibiting the activation of a STING signaling pathway and for preparing a drug for preventing or treating a disease mediated by STING.
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Inventors:
SUN HONGBIN (CN)
WANG CHEN (CN)
YOU YANPING (CN)
SUN LI (CN)
HONG ZE (CN)
PAN YANHONG (CN)
SUI QIBANG (CN)
ZANG YONGJUN (CN)
YUAN HAOLIANG (CN)
WEN XIAOAN (CN)
XU QINGLONG (CN)
LIU JUN (CN)
WANG CHEN (CN)
YOU YANPING (CN)
SUN LI (CN)
HONG ZE (CN)
PAN YANHONG (CN)
SUI QIBANG (CN)
ZANG YONGJUN (CN)
YUAN HAOLIANG (CN)
WEN XIAOAN (CN)
XU QINGLONG (CN)
LIU JUN (CN)
Application Number:
PCT/CN2020/120279
Publication Date:
April 15, 2021
Filing Date:
October 12, 2020
Export Citation:
Assignee:
UNIV CHINA PHARMA (CN)
International Classes:
A61P3/00; C07C311/21; A61P29/00; A61P31/00; A61P31/06; A61P35/00; A61P37/02; C07C311/29; C07D215/48; C07D239/26; C07D241/12; C07D271/12; C07D317/60; C07D319/18; C07D333/24
Domestic Patent References:
| WO2009086303A2 | 2009-07-09 |
Foreign References:
| CN105579457A | 2016-05-11 | |||
| CN105228982A | 2016-01-06 | |||
| CN105579457A | 2016-05-11 | |||
| CN108064222A | 2018-05-22 |
Other References:
“RN2249435-90-1” REGISTRY, 18 November 2018 (2018-11-18)
DATABASE Registry STN; ANONYMOUS: "[1,1'-Biphenyl]-4-carboxamide, N-[4-methoxy-3- [(methylsulfonyl)amino]phenyl]", XP055800954
SIU, T. ET AL.: "Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING", ACS MEDICINAL CHEMISTRY LETTERS, vol. 10, no. 1, 6 December 2018 (2018-12-06), XP055684851, ISSN: 1948-5875, DOI: 10.1021/acsmedchemlett.8b00466
LI SENLIN, HONG ZE, WANG ZHE, LI FEI, MEI JIAHAO, HUANG LULU, LOU XIWEN, ZHAO SIMENG, SONG LIHUA, CHEN WEI, WANG QIANG, LIU HENG, : "The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING", CELL REPORTS, ELSEVIER INC, US, vol. 25, no. 12, 1 December 2018 (2018-12-01), US, pages 3405 - 3421.e7, XP055800947, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.11.097
DATABASE Registry STN; ANONYMOUS: "[1,1'-Biphenyl]-4-carboxamide, N-[4-methoxy-3- [(methylsulfonyl)amino]phenyl]", XP055800954
SIU, T. ET AL.: "Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING", ACS MEDICINAL CHEMISTRY LETTERS, vol. 10, no. 1, 6 December 2018 (2018-12-06), XP055684851, ISSN: 1948-5875, DOI: 10.1021/acsmedchemlett.8b00466
LI SENLIN, HONG ZE, WANG ZHE, LI FEI, MEI JIAHAO, HUANG LULU, LOU XIWEN, ZHAO SIMENG, SONG LIHUA, CHEN WEI, WANG QIANG, LIU HENG, : "The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING", CELL REPORTS, ELSEVIER INC, US, vol. 25, no. 12, 1 December 2018 (2018-12-01), US, pages 3405 - 3421.e7, XP055800947, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.11.097
Attorney, Agent or Firm:
NANJING SUGAO PATENT AND TRADEMARK FIRM ( ORDINARY PARTNERSHIP ) (CN)
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