AMINO ACID DERIVATIVE

Title:

AMINO ACID DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/1993/001163

Kind Code:

A1

Abstract:

Constitution: an amino acid derivative represented by the general formula (I): R1NH-CH(R2)-CONH-A-ONO2 and a pharmacologically acceptable salt thereof, wherein R1 represents hydrogen, C1-C7 alkanoyl, C1-C6 alkoxycarbonyl, C6-C10 arylcarbonyl, C7-C13 aralkylcarbonyl, C7-C13 aralkyloxycarbonyl, or 5- or 6-membered heteroarylcarbonyl; R2 represents substituted C1-C6 alkyl; and A represents C2-C5 alkylene. Effect: this compound is excellent in a collateral vessel dilator activity and an antianginal activity, and hence useful as an antianginal drug.

Inventors:

ISHIHARA SADAO (JP)
SAITO FUJIO (JP)
YOSHIOKA TAKAO (JP)
KOIKE HIROYUKI (JP)
MIYAKE SHIGEKI (JP)
MIZUNO HIROSHI (JP)

Application Number:

PCT/JP1992/000823

Publication Date:

January 21, 1993

Filing Date:

June 30, 1992

Export Citation:

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Assignee:

SANKYO CO (JP)

International Classes:

A61K31/40; A61K31/403; A61K31/404; A61K31/41; A61K31/425; A61K31/426; A61K31/465; A61P9/08; A61P9/10; C07C237/08; C07C237/12; C07C237/20; C07C237/22; C07C237/34; C07C271/22; C07C323/60; A61K31/27; C07C327/06; C07C327/16; C07C327/34; C07C329/06; C07D209/18; C07D209/20; C07D213/32; C07D213/81; C07D213/82; C07D213/83; C07D233/54; C07D233/64; C07D277/20; C07D277/30; C07D307/68; C07D309/08; C07D317/38; C07D333/38; (IPC1-7): A61K31/27; A61K31/40; A61K31/41; A61K31/425; A61K31/465; C07C237/08; C07C237/22; C07C323/60; C07C327/04; C07C327/16; C07C329/06; C07D209/20; C07D213/32; C07D233/64; C07D277/30

Foreign References:

JPS63233962A	1988-09-29
JPH02169558A	1990-06-29

Other References: