Title:
AMINO-SILA-PYRONIN COMPOUND-BASED ONE- OR TWO-PHOTON ABSORPTION FLUORESCENT SUBSTANCE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/045522
Kind Code:
A1
Abstract:
The present invention relates to a silicon-substituted amino-pyronin compound derivative, a cell- or tissue-imaging method using the same, a cancer diagnosis method using the same, and a method for preparation of the same. More specifically, serving as a two-photon absorption fluorescent substance which has longer absorption and emission wavelengths in red or near-infrared regions of 625 nm or greater, compared to conventional one-photon absorption fluorescent substances, the silicon-substituted amino-pyronin compound derivative can minimize the influence of self-fluorescence in a bioimaging study and is thus expected to be suitable for high-resolution imaging in deep tissues. A fluorescent probe developed on the basis of the fluorescent substance platform is expected to find an expanded range of applications in analyzing and imaging specific materials in vivo.
Inventors:
AHN KYO HAN (KR)
RYU HYE GUN (KR)
KIM KYEONG HWAN (KR)
JUN YONG WOONG (KR)
SINGHA SUBHANKAR (KR)
RYU HYE GUN (KR)
KIM KYEONG HWAN (KR)
JUN YONG WOONG (KR)
SINGHA SUBHANKAR (KR)
Application Number:
PCT/KR2018/010154
Publication Date:
March 07, 2019
Filing Date:
August 31, 2018
Export Citation:
Assignee:
POSTECH ACAD IND FOUND (KR)
International Classes:
C07F7/08; A61K49/00
Domestic Patent References:
| WO2015097262A1 | 2015-07-02 | |||
| WO2016109733A1 | 2016-07-07 |
Other References:
BUTKEVICH, A. N.: "Cell -Permeant Large Stokes Shift Dyes for Transfection -Free Multicolor Nanoscopy", J. AM. CHEM. SOC., 28 August 2017 (2017-08-28), pages 12378 - 12381, XP055579810
HORVATH, P.: "Small-Molecule Fluorophores with Large Stokes Shifts: 9-Imi nopyronin Analogues as Clickable Tags", J. ORG. CHEM., vol. 80, no. 3, 8 December 2014 (2014-12-08), pages 1299 - 1311, XP055579813
MUDD, G.: "A general synthetic route to isomerically pure functionalized rhodamine dyes", METHODS APPL. FLUORESC., vol. 3, 14 October 2015 (2015-10-14), pages 1 - 6, XP055579818
HORVATH, P.: "Small-Molecule Fluorophores with Large Stokes Shifts: 9-Imi nopyronin Analogues as Clickable Tags", J. ORG. CHEM., vol. 80, no. 3, 8 December 2014 (2014-12-08), pages 1299 - 1311, XP055579813
MUDD, G.: "A general synthetic route to isomerically pure functionalized rhodamine dyes", METHODS APPL. FLUORESC., vol. 3, 14 October 2015 (2015-10-14), pages 1 - 6, XP055579818
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
Download PDF:
Previous Patent: ELECTRONIC DEVICE AND CONTROL METHOD THEREFOR
Next Patent: DEVICE AND METHOD FOR TRANSPORTING LIQUID CARGO IN PRESSURIZATION TYPE
Next Patent: DEVICE AND METHOD FOR TRANSPORTING LIQUID CARGO IN PRESSURIZATION TYPE