AMINOQUINAZOLINE DERIVATIVES AND THEIR SALTS WITH ANTINEOPLASTIC ACTIVITY

Title:

AMINOQUINAZOLINE DERIVATIVES AND THEIR SALTS WITH ANTINEOPLASTIC ACTIVITY

Document Type and Number:

WIPO Patent Application WO/2010/037339

Kind Code:

A1

Abstract:

The present invention provides aminoquinazoline derivatives and their salts which possess antineoplastic activity and can inhibit the signal conduction of epidermal growth factor receptor. These new aminoquinazoline compounds possess very high activity on inhibiting growth of tumor cells, and in particular, possess remarkably inhibiting effect on tumor cells with highly expressed EGFR, and their semi-effective inhibition concentration is 5 times more than that of market drugs IRESSA.

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Inventors:

ZHANG JIANCUN (CN)
ZHENG JIANLONG (CN)
HUANG XIAOGUANG (CN)

Application Number:

PCT/CN2009/074183

Publication Date:

April 08, 2010

Filing Date:

September 24, 2009

Export Citation:

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Assignee:

GUANGZHOU INST BIOMED & HEALTH (CN)
ZHANG JIANCUN (CN)
ZHENG JIANLONG (CN)
HUANG XIAOGUANG (CN)

International Classes:

C07D401/12; A61K31/506; A61P35/00; C07D403/12; C07D487/08; C07D495/08

Foreign References:

CN101367793A	2009-02-18
CN101289445A	2008-10-22
CN1182421A	1998-05-20
CN1343201A	2002-04-03

Attorney, Agent or Firm:

ADVANCE CHINA I. P. LAW OFFICE (Suite 918-920 9/F., Dong Shan Plaza, No. 69 Xianlie Central Roa, Guangzhou Guangdong 5, CN)

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