AMORPHOUS SOLID DISPERSION COMPRISING (S) -1- (1-ACRYLOYLPYRROLIDIN-3-YL) -3- ( (3, 5-DIMETHOXYPHENYL) ETHYNYL) -5- (METHYLAMINO) -1H-PYRAZOLE-4-CARBOXAMIDE

Title:

AMORPHOUS SOLID DISPERSION COMPRISING (S) -1- (1-ACRYLOYLPYRROLIDIN-3-YL) -3- ( (3, 5-DIMETHOXYPHENYL) ETHYNYL) -5- (METHYLAMINO) -1H-PYRAZOLE-4-CARBOXAMIDE

Document Type and Number:

WIPO Patent Application WO/2023/078179

Kind Code:

A1

Abstract:

The present invention provides an amorphous solid dispersion comprises (S) -1- (1-acryloylpyrrolidin-3-yl) -3- ( (3, 5-dimethoxyphenyl) ethynyl) -5- (methylamino) -1H-pyrazole-4-carboxamide (Compound I) and a pharmaceutically acceptable polymer, and a pharmaceutical composition comprising the amorphous solid dispersion. The amorphous solid dispersion of the present invention is stable upon storage and provides better solubility and bioavailability when comparing with a crystalline form.

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Inventors:

CHEN XIANGYANG (CN)

Application Number:

PCT/CN2022/128315

Publication Date:

May 11, 2023

Filing Date:

October 28, 2022

Export Citation:

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Assignee:

BEIJING INNOCARE PHARMA TECH CO LTD (CN)

International Classes:

A61K31/4155; A61K9/14; A61K9/20; A61K9/48; A61K47/38

Domestic Patent References:

WO2021129565A1	2021-07-01
WO2018049781A1	2018-03-22
WO2020208592A1	2020-10-15
WO2007129066A1	2007-11-15

Foreign References:

CN113490492A

2021-10-08

Attorney, Agent or Firm:

INTELIGHT IP LAW FIRM (CN)

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