Title:
AMPHIPATIC POLYCARBOXYLIC CHELATES AND COMPLEXES WITH PARAMAGNETIC METALS AS MRI CONTRAST AGENTS
Document Type and Number:
WIPO Patent Application WO2000030688
Kind Code:
A3
Abstract:
Substituted polycarboxylic ligand molecules and corresponding metal complexes of said ligands, preferably paramagnetic metals complexes for generating responses in the field of magnetic resonance imaging (MRI). The paramagnetic complexes of the polycarboxylic ligands possess advantageous tensioactive properties and are useful as MRI contrast media in formulations for investigating the blood pool.
Inventors:
ANELLI PIER LUCIO
LATTUADA LUCIANO
UGGERI FULVIO
LUX GIOVANNA
SERLETI MICHELE
GABELLINI MILENA
TOURNIER HERVE
LATTUADA LUCIANO
UGGERI FULVIO
LUX GIOVANNA
SERLETI MICHELE
GABELLINI MILENA
TOURNIER HERVE
Application Number:
PCT/IB1999/001889
Publication Date:
November 09, 2000
Filing Date:
November 25, 1999
Export Citation:
Assignee:
BRACCO INT BV (NL)
International Classes:
A61K49/00; A61K49/06; A61K49/18; C07C229/16; C07C229/76; C07C233/47; C07C237/08; C07C237/10; C07C237/12; C07D257/02; C07F9/09; C07J41/00; (IPC1-7): C07F9/09; A61K49/00; C07J41/00; C07D257/02
Domestic Patent References:
| WO1997000087A1 | 1997-01-03 | |||
| WO1994027977A1 | 1994-12-08 | |||
| WO1995028967A1 | 1995-11-02 | |||
| WO1996011023A1 | 1996-04-18 | |||
| WO1992021017A1 | 1992-11-26 | |||
| WO1995028392A1 | 1995-10-26 |
Foreign References:
| EP0872479A1 | 1998-10-21 | |||
| EP0485045A2 | 1992-05-13 |
Other References:
JASANADA, FRANCOIS ET AL: "Synthesis of amphiphilic chelating agents: bis(hexadecylamide) and bis(octadecylamide) of diethylenetriaminepentaacetic acid", TETRAHEDRON LETT. (1992), 33(39), 5745-8, 1992, XP002115955
KABALKA, G. W. ET AL: "Gadolinium-labeled liposomes containing various amphiphilic gadolinium-DTPA derivatives: targeted MRI contrast enhancement agents for the liver", MAGN. RESON. MED. (1991), 19(2), 406-15, 1991, XP002115956
HNATOWICH D J ET AL: "LABELING OF PREFORMED LIPOSOMES WITH GA-67 AND TC-99M BY CHELATION", JOURNAL OF NUCLEAR MEDICINE, vol. 22, no. 9, 1 September 1981 (1981-09-01), pages 810 - 814, XP000568001, ISSN: 0161-5505
KABALKA, G. W. ET AL: "Gadolinium-labeled liposomes containing various amphiphilic gadolinium-DTPA derivatives: targeted MRI contrast enhancement agents for the liver", MAGN. RESON. MED. (1991), 19(2), 406-15, 1991, XP002115956
HNATOWICH D J ET AL: "LABELING OF PREFORMED LIPOSOMES WITH GA-67 AND TC-99M BY CHELATION", JOURNAL OF NUCLEAR MEDICINE, vol. 22, no. 9, 1 September 1981 (1981-09-01), pages 810 - 814, XP000568001, ISSN: 0161-5505
Download PDF:
Previous Patent: MEDICINAL COMPOSITIONS FOR PERIODIC ADMINISTRATION
Next Patent: IMPROVED UNCOMPLEXED CYCLODEXTRIN COMPOSITIONS FOR ODOR CONTROL
Next Patent: IMPROVED UNCOMPLEXED CYCLODEXTRIN COMPOSITIONS FOR ODOR CONTROL