MEDICINAL COMPOSITIONS FOR PERIODIC ADMINISTRATION

Title:

MEDICINAL COMPOSITIONS FOR PERIODIC ADMINISTRATION

Document Type and Number:

WIPO Patent Application WO/2000/030684

Kind Code:

A1

Abstract:

In the case of administering an estrogen antagonist for treating or preventing endometriosis and/or menstrual abnormality, it is needless to administer the drug constantly and continuously during the period with a need of the treatment or prevention (i.e., chronic administration) but almost comparable therapeutic effects to those of the chronic administration can be achieved by continuously administering for 5 to 13 days from the menstrual period to immediately before ovulation (i.e., periodic administration). Moreover, the periodic administration is almost completely free from such side effects as observed in the case of the chronic administration of the estrogen antagonist. Thus, the periodic administration is a useful method for administering the estrogen antagonist for treating or preventing endometriosis and/or menstrual abnormality.

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Inventors:

TAKAHASHI HIROO (JP)
FUJII TOMOHITO (JP)
SHIMIZU YASUSHI (JP)
SATO KODO (JP)

Application Number:

PCT/JP1999/006383

Publication Date:

June 02, 2000

Filing Date:

November 16, 1999

Export Citation:

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Assignee:

TEIKOKU HORMONE MFG CO LTD (JP)
TAKAHASHI HIROO (JP)
FUJII TOMOHITO (JP)
SHIMIZU YASUSHI (JP)
SATO KODO (JP)

International Classes:

A61K31/381; A61K45/00; A61P15/00; C07D333/56; (IPC1-7): A61K45/00; A61K31/381; A61P15/00

Foreign References:

EP0641791A1

1995-03-08

Other References:

GROOM G.V. ET AL.: "Effect of the anti-oestrogen tamoxifen on plasma levels of luteinizing hormone follicle-stimulating hormone, prolactin, oestradiol and progesterone in normal pre-menopausal women", J. ENDOCR.,, vol. 70, no. 3, 1976, pages 421 - 428, XP002925248
See also references of EP 1133996A4

Attorney, Agent or Firm:

Odajima, Heikichi (Akasaka 1-chome Minato-ku Tokyo, JP)

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