Title:
ANALOGS FOR THE TREATMENT OF DISEASE
Document Type and Number:
WIPO Patent Application WO/2022/179528
Kind Code:
A1
Abstract:
Provided are TNIK and/or MAP4K4 kinases inhibitors for the treatment of disease. In one aspect, disclosed herein are kinase inhibitors having a structure of Formula (A), (A*), (I), (IIA), or (IIB). Further described herein are pharmaceutical composition comprising these compounds and methods of using these compounds. In one aspect, disclosed herein are methods of treating a disease or condition by administering the kinases inhibitors described herein.
Inventors:
ZAVORONKOVS ALEKSANDRS (CN)
ALIPER ALEKSANDR (RU)
ALADINSKIY VLADIMIR (RU)
KUKHARENKO ANDREY (RU)
ALIPER ALEKSANDR (RU)
ALADINSKIY VLADIMIR (RU)
KUKHARENKO ANDREY (RU)
Application Number:
PCT/CN2022/077477
Publication Date:
September 01, 2022
Filing Date:
February 23, 2022
Export Citation:
Assignee:
INSILICO MEDICINE IP LTD (CN)
International Classes:
C07D405/04; A61K31/4164; A61P35/00; C07D401/14; C07D403/04; C07D405/14; C07D409/04; C07D413/04; C07D417/04
Domestic Patent References:
WO2020170202A1 | 2020-08-27 | |||
WO2010090716A1 | 2010-08-12 | |||
WO2016038583A1 | 2016-03-17 | |||
WO2002088097A1 | 2002-11-07 |
Foreign References:
CN1505628A | 2004-06-16 |
Other References:
DATABASE REGISTRY 19 April 2018 (2018-04-19), ANONYMOUS : " -3-Pyridinecarboxamide, 2-(1-methyl-1H-imidazol-5-yl)-N-[4-(4-methyl-1- piperazinyl)phenyl]-(CA INDEX NAME) ", XP055961719, retrieved from STN Database accession no. 2215364-32-0
Attorney, Agent or Firm:
AFD CHINA INTELLECTUAL PROPERTY LAW OFFICE (CN)
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