Title:
ANALOGS FOR THE TREATMENT OF DISEASE
Document Type and Number:
WIPO Patent Application WO/2022/179529
Kind Code:
A1
Abstract:
Provided are TNIK and/or MAP4K4 kinases inhibitors for the treatment of disease. In one aspect, disclosed herein are kinase inhibitors having a structure of Formulas (A), (A*), (I), (II), (AA), (B), (C), (D), (B*), (C*) and (D*). Further described herein are pharmaceutical composition comprising these compounds and methods of using these compounds. In one aspect, disclosed herein are methods of treating a disease or condition by administering the kinases inhibitors described herein.
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Inventors:
ZAVORONKOVS ALEKSANDRS (CN)
ALIPER ALEKSANDR (RU)
ALADINSKIY VLADIMIR (RU)
KUKHARENKO ANDREY (RU)
QIN LUOHENG (CN)
CHENG XIN (CN)
ALIPER ALEKSANDR (RU)
ALADINSKIY VLADIMIR (RU)
KUKHARENKO ANDREY (RU)
QIN LUOHENG (CN)
CHENG XIN (CN)
Application Number:
PCT/CN2022/077478
Publication Date:
September 01, 2022
Filing Date:
February 23, 2022
Export Citation:
Assignee:
INSILICO MEDICINE IP LTD (CN)
International Classes:
C07D405/04; A61K31/4164; A61P35/00; C07D401/14; C07D403/04; C07D405/14; C07D409/04; C07D413/04; C07D417/04
Domestic Patent References:
| WO2020170202A1 | 2020-08-27 | |||
| WO2010090716A1 | 2010-08-12 | |||
| WO2016038583A1 | 2016-03-17 | |||
| WO2002088097A1 | 2002-11-07 |
Foreign References:
| CN1505628A | 2004-06-16 |
Other References:
DATABASE REGISTRY 19 April 2018 (2018-04-19), ANONYMOUS: "3-Pyridinecarboxamide, 2-(1-methyl-1H-imidazol-5-yl)-N-[4-(4-methyl-1- piperazinyl)phenyl]- (CA INDEX NAME)", XP055961719, retrieved from STN Database accession no. 2215364-32-0
Attorney, Agent or Firm:
AFD CHINA INTELLECTUAL PROPERTY LAW OFFICE (CN)
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