Title:
ANALOGUES OF AZABICYCLIC COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2023/238930
Kind Code:
A1
Abstract:
Provided are novel compounds which are analogues to be removed from APIs and formulations. Also provided are standard products of analogues to be used in controlling the qualities of medicines. Analogue 1: 3-ethyl-4-\{4-[4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl]-3,3'-di(propan-2-yl)-1'H-[1,4'-bipyrazolo[3,4-b]pyridin]-1'-yl\}benzamide. Analogue 2: 3-ethyl-4-fuluorobenzamide. Analogue 3: N-[1-(4-carbamoyl-2-ethylphenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-3-ethyl-4-\{4-[4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl\}benzamide. Analogue 4: 3-ethyl-4-\{14-[4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl]-13,23,33-tri(propan-2-yl)-31H-[11,24:21, 34-terpyrazolo[3,4-b]pyridin]-31-yl\}benzamide. Analogue 5: 4,4'-(1H,1'H-[4,4'-biimidazol]-1,1'-diylbis\{[3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridin-4,1-diyl]\})bis(3-ethylbenzamide). Analogue 6: 4-\{4,6-bis[4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridin]-1-yl\}-3-ethylbenzonitrile. Analogue 7: 4-\{4,6-bis[4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl\}-3-ethylbenzamide. Analogue 8: 4-[4-ethoxy-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl]-3-ethylbenzamide. Analogue 9: 3-ethyl-4-[4-methoxy-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl]benzamide.
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Inventors:
WADA SHIRO (JP)
Application Number:
PCT/JP2023/021536
Publication Date:
December 14, 2023
Filing Date:
June 09, 2023
Export Citation:
Assignee:
TAIHO PHARMACEUTICAL CO LTD (JP)
International Classes:
C07C233/65; A61K31/166; A61K31/437; A61P35/00; C07D471/04; C07D519/00
Domestic Patent References:
| WO2016181990A1 | 2016-11-17 |
Foreign References:
| JP2010535192A | 2010-11-18 |
Other References:
YOSHIMURA CHIHOKO, NAGATOISHI SATORU, KURODA DAISUKE, KODAMA YASUO, UNO TAKAO, KITADE MAKOTO, CHONG-TAKATA KHOONTEE, OSHIUMI HIROM: "Thermodynamic Dissection of Potency and Selectivity of Cytosolic Hsp90 Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 64, no. 5, 11 March 2021 (2021-03-11), US , pages 2669 - 2677, XP093114780, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.0c01715
ANONYMOUS: "Guideline Concerning Active Ingredient Impurities in New Active Component-Containing Drugs", PFSB / ELD NOTIFICATION NO. 1216001, 16 December 2002 (2002-12-16), XP093114781
KAZUKO YAMASHITA; MASAHIKO OKAMOTO; KIYOSHI NAKAI: "Development of an On-line Sample Enrichment System Coupled to ESI-TOFMS- Challenge to highly sensitive structural elucidation of impurities of agrochemicals and pharmaceuticals-", SUMOTOMO KAGAKU. TOKUSHU-GO, SUMOTOMO KAGAKU KOGYO KABUSHIKI GAISHA, OSAKA, JP, vol. 2002, no. 2, 30 November 2001 (2001-11-30), JP , pages 56 - 64, XP009530483, ISSN: 0387-1312
TOMONORI MURAKAMI, NAOTO FUKUTSU: "Structure Elucidation of Impurities in Pharmaceuticals by HPLC Hyphenated Techniques", CHROMATOGRAPHY, KUROMATOGURAFI KAGAKKAI, JP, vol. 33, no. 3, 1 December 2012 (2012-12-01), JP , pages 179 - 190, XP009530484, ISSN: 1342-8284
UNO TAKAO, SHUICHI OHKUBO, MAKOTO KITADE: "Discovery of TAS-116 as a novel orally available HSP90 inhibitor", MEDCHEM NEWS, vol. 30, no. 3, 1 January 2020 (2020-01-01), pages 133 - 136, XP093114783
ANONYMOUS: "Guideline Concerning Active Ingredient Impurities in New Active Component-Containing Drugs", PFSB / ELD NOTIFICATION NO. 1216001, 16 December 2002 (2002-12-16), XP093114781
KAZUKO YAMASHITA; MASAHIKO OKAMOTO; KIYOSHI NAKAI: "Development of an On-line Sample Enrichment System Coupled to ESI-TOFMS- Challenge to highly sensitive structural elucidation of impurities of agrochemicals and pharmaceuticals-", SUMOTOMO KAGAKU. TOKUSHU-GO, SUMOTOMO KAGAKU KOGYO KABUSHIKI GAISHA, OSAKA, JP, vol. 2002, no. 2, 30 November 2001 (2001-11-30), JP , pages 56 - 64, XP009530483, ISSN: 0387-1312
TOMONORI MURAKAMI, NAOTO FUKUTSU: "Structure Elucidation of Impurities in Pharmaceuticals by HPLC Hyphenated Techniques", CHROMATOGRAPHY, KUROMATOGURAFI KAGAKKAI, JP, vol. 33, no. 3, 1 December 2012 (2012-12-01), JP , pages 179 - 190, XP009530484, ISSN: 1342-8284
UNO TAKAO, SHUICHI OHKUBO, MAKOTO KITADE: "Discovery of TAS-116 as a novel orally available HSP90 inhibitor", MEDCHEM NEWS, vol. 30, no. 3, 1 January 2020 (2020-01-01), pages 133 - 136, XP093114783
Attorney, Agent or Firm:
ARUGA PATENT OFFICE (JP)
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