Title:
ANGIOTENSIN-CONVERTING-ENZYME INHIBITING DIPEPTIDE
Document Type and Number:
WIPO Patent Application WO/2014/002571
Kind Code:
A1
Abstract:
[Problem] To provide a useful dipeptide-containing composition derived from dried bonito flakes and the like, having an angiotensin-converting-enzyme inhibiting activity that imparts a blood pressure reducing function. [Solution] A composition containing a dipeptide derived from a fish meat protein having an angiotensin-converting-enzyme inhibiting activity. The composition is characterised by containing: at least one type of dipeptide selected from the group consisting of a dipeptide consisting of a tryptophan-leucine amino acid sequence, a dipeptide consisting of a leucine-tryptophan amino acid sequence, a dipeptide consisting of a tryptophan-isoleucine amino acid sequence, a dipeptide consisting of a valine-triptophan sequence, a dipeptide consisting of a tryptophan-tyrosine sequence, a dipeptide consisting of a tryptophan-methonine sequence, a dipeptide consisting of a serin-triptophan sequence, and a dipeptide consisting of an asparagine-triptophan sequence; and/or an acid addition salt of said dipeptide(s).
Inventors:
SEKI EIJI (JP)
ASADA HITOSHI (JP)
ASADA HITOSHI (JP)
Application Number:
PCT/JP2013/060847
Publication Date:
January 03, 2014
Filing Date:
April 10, 2013
Export Citation:
Assignee:
YAMAKI CO LTD (JP)
International Classes:
C07K5/062; A23L1/305; A61K38/00; A61P9/12; A61P43/00; C07K5/072; C07K5/078
Foreign References:
| JP2001112470A | 2001-04-24 | |||
| JP2010155788A | 2010-07-15 | |||
| EP2161029A1 | 2010-03-10 | |||
| JP2010163400A | 2010-07-29 | |||
| JP2008308445A | 2008-12-25 | |||
| JP2013071897A | 2013-04-22 |
Other References:
HIDEKI MATSUDA ET AL.: "Shokuhin Kogyoyo Ianpakushitsu Bunkai Koso ni yotte Iwashi Kinniku kara Erareta Angiotensin I Henkan Koso Sogai Dipeptide", NIHON SHOKUHIN KOGYO SAKKAISHI, vol. 39, no. 8, 1992, pages 678 - 683
ENARI H. ET AL.: "Identification of angiotensin I-converting enzyme inhibitory peptides derived from salmon muscle and their antihypertensive effect", FISH. SCI., vol. 74, no. 4, 2008, pages 911 - 920
YOKOYAMA K. ET AL.: "Peptide inhibitors for angiotensin I-converting enzyme from thermolysin digest of dried bonito", BIOSCI. BIOTECHNOL. BIOCHEM., vol. 56, no. 10, 1992, pages 1541 - 1545
ENARI H. ET AL.: "Identification of angiotensin I-converting enzyme inhibitory peptides derived from salmon muscle and their antihypertensive effect", FISH. SCI., vol. 74, no. 4, 2008, pages 911 - 920
YOKOYAMA K. ET AL.: "Peptide inhibitors for angiotensin I-converting enzyme from thermolysin digest of dried bonito", BIOSCI. BIOTECHNOL. BIOCHEM., vol. 56, no. 10, 1992, pages 1541 - 1545
Attorney, Agent or Firm:
HAMANO, TAKAO (JP)
Takao Hamano (JP)
Takao Hamano (JP)
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