Title:
ANTAGONISTIC ANTI-CANINE PD-1 ANTIBODIES
Document Type and Number:
WIPO Patent Application WO/2015/091911
Kind Code:
A3
Abstract:
The present invention discloses antibodies to canine PD-1 that have specific sequences and a high binding affinity for canine PD-1. The invention also discloses the use of the antibodies of the present invention in the treatment of cancer in dogs.
Inventors:
MORSEY MOHAMAD (US)
ZHANG YUANZHENG (US)
BARTELS-MOROZOV DENISE (US)
ERSKINE JASON (US)
TARPEY IAN (GB)
ZHANG YUANZHENG (US)
BARTELS-MOROZOV DENISE (US)
ERSKINE JASON (US)
TARPEY IAN (GB)
Application Number:
PCT/EP2014/078655
Publication Date:
October 15, 2015
Filing Date:
December 19, 2014
Export Citation:
Assignee:
INTERVET INT BV (NL)
INTERVET INC (US)
INTERVET INC (US)
International Classes:
C07K16/28; A61K39/00; A61P31/00; A61P35/00
Domestic Patent References:
| WO2008083174A2 | 2008-07-10 | |||
| WO2013124666A1 | 2013-08-29 |
Other References:
"PREDICTED: programmed cell death protein 1 [Canis lupus familiaris] - Protein - NCBI", NCBI REFERENCE SEQUENCE: XP_543338.3, 24 September 2013 (2013-09-24), XP055179334, Retrieved from the Internet [retrieved on 20150325]
DAVID P GEARING ET AL: "A fully caninised anti-NGF monoclonal antibody for pain relief in dogs", BMC VETERINARY RESEARCH, BIOMED CENTRAL, LONDON, GB, vol. 9, no. 1, 9 November 2013 (2013-11-09), pages 226, XP021168653, ISSN: 1746-6148, DOI: 10.1186/1746-6148-9-226
K. J. ESCH ET AL: "Programmed Death 1-Mediated T Cell Exhaustion during Visceral Leishmaniasis Impairs Phagocyte Function", THE JOURNAL OF IMMUNOLOGY, vol. 191, no. 11, 23 October 2013 (2013-10-23), pages 5542 - 5550, XP055179314, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1301810
S. LYFORD-PIKE ET AL: "Evidence for a Role of the PD-1:PD-L1 Pathway in Immune Resistance of HPV-Associated Head and Neck Squamous Cell Carcinoma", CANCER RESEARCH, vol. 73, no. 6, 3 January 2013 (2013-01-03), pages 1733 - 1741, XP055179352, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-12-2384
COBBOLD S ET AL: "The immunology of companion animals: reagents and therapeutic strategies with potential veterinary and human clinical applications", IMMUNOLOGY TODAY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, vol. 15, no. 8, 1 August 1994 (1994-08-01), pages 347 - 353, XP023937839, ISSN: 0167-5699, [retrieved on 19940801], DOI: 10.1016/0167-5699(94)90171-6
TANG LIANG ET AL: "Cloning and characterization of cDNAs encoding four different canine immunoglobulin gamma chains", VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, ELSEVIER BV, AMSTERDAM, NL, vol. 80, no. 3-4, 10 August 2001 (2001-08-10), pages 259 - 270, XP002616920, ISSN: 0165-2427, DOI: 10.1016/S0165-2427(01)00318-X
BERGERON LISA M ET AL: "Comparative functional characterization of canine IgG subclasses", VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, vol. 157, no. 1, 1 November 2013 (2013-11-01), pages 31 - 41, XP028801783, ISSN: 0165-2427, DOI: 10.1016/J.VETIMM.2013.10.018
RUDIKOFF S ET AL: "Single amino acid substitution altering antigen-binding specificity", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 79, 1 March 1982 (1982-03-01), pages 1979 - 1983, XP007901436, ISSN: 0027-8424, DOI: 10.1073/PNAS.79.6.1979
YEE WAH WONG ET AL: "Structural Requirements for a Specificity Switch and for Maintenance of Affinity Using Mutational Analysis of a Phage-Displayed Anti-Arsonate Antibody of Fab Heavy Chain First Complementarity-Determining Region", THE JOURNAL OF IMMUNOLOGY, THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, vol. 160, 1 January 1998 (1998-01-01), pages 5990 - 5997, XP007916801, ISSN: 0022-1767
JEFFEREY R JACKSON: "In Vitro Antibody Maturation Improvement of a High Affinity, Neutralizing Antibody Against IL-1 beta", THE JOURNAL OF IMMUNOLOGY, vol. 154, 1 January 1995 (1995-01-01), pages 3310 - 3319, XP055033979
DAVID F. MCDERMOTT ET AL: "PD-1 as a potential target in cancer therapy", CANCER MEDICINE, 21 July 2013 (2013-07-21), pages n/a - n/a, XP055157252, ISSN: 2045-7634, DOI: 10.1002/cam4.106
DAVID P GEARING ET AL: "A fully caninised anti-NGF monoclonal antibody for pain relief in dogs", BMC VETERINARY RESEARCH, BIOMED CENTRAL, LONDON, GB, vol. 9, no. 1, 9 November 2013 (2013-11-09), pages 226, XP021168653, ISSN: 1746-6148, DOI: 10.1186/1746-6148-9-226
K. J. ESCH ET AL: "Programmed Death 1-Mediated T Cell Exhaustion during Visceral Leishmaniasis Impairs Phagocyte Function", THE JOURNAL OF IMMUNOLOGY, vol. 191, no. 11, 23 October 2013 (2013-10-23), pages 5542 - 5550, XP055179314, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1301810
S. LYFORD-PIKE ET AL: "Evidence for a Role of the PD-1:PD-L1 Pathway in Immune Resistance of HPV-Associated Head and Neck Squamous Cell Carcinoma", CANCER RESEARCH, vol. 73, no. 6, 3 January 2013 (2013-01-03), pages 1733 - 1741, XP055179352, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-12-2384
COBBOLD S ET AL: "The immunology of companion animals: reagents and therapeutic strategies with potential veterinary and human clinical applications", IMMUNOLOGY TODAY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, vol. 15, no. 8, 1 August 1994 (1994-08-01), pages 347 - 353, XP023937839, ISSN: 0167-5699, [retrieved on 19940801], DOI: 10.1016/0167-5699(94)90171-6
TANG LIANG ET AL: "Cloning and characterization of cDNAs encoding four different canine immunoglobulin gamma chains", VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, ELSEVIER BV, AMSTERDAM, NL, vol. 80, no. 3-4, 10 August 2001 (2001-08-10), pages 259 - 270, XP002616920, ISSN: 0165-2427, DOI: 10.1016/S0165-2427(01)00318-X
BERGERON LISA M ET AL: "Comparative functional characterization of canine IgG subclasses", VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, vol. 157, no. 1, 1 November 2013 (2013-11-01), pages 31 - 41, XP028801783, ISSN: 0165-2427, DOI: 10.1016/J.VETIMM.2013.10.018
RUDIKOFF S ET AL: "Single amino acid substitution altering antigen-binding specificity", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 79, 1 March 1982 (1982-03-01), pages 1979 - 1983, XP007901436, ISSN: 0027-8424, DOI: 10.1073/PNAS.79.6.1979
YEE WAH WONG ET AL: "Structural Requirements for a Specificity Switch and for Maintenance of Affinity Using Mutational Analysis of a Phage-Displayed Anti-Arsonate Antibody of Fab Heavy Chain First Complementarity-Determining Region", THE JOURNAL OF IMMUNOLOGY, THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, vol. 160, 1 January 1998 (1998-01-01), pages 5990 - 5997, XP007916801, ISSN: 0022-1767
JEFFEREY R JACKSON: "In Vitro Antibody Maturation Improvement of a High Affinity, Neutralizing Antibody Against IL-1 beta", THE JOURNAL OF IMMUNOLOGY, vol. 154, 1 January 1995 (1995-01-01), pages 3310 - 3319, XP055033979
DAVID F. MCDERMOTT ET AL: "PD-1 as a potential target in cancer therapy", CANCER MEDICINE, 21 July 2013 (2013-07-21), pages n/a - n/a, XP055157252, ISSN: 2045-7634, DOI: 10.1002/cam4.106
Attorney, Agent or Firm:
INTERVET INTERNATIONAL BV ASS. NO. 666 et al. (5831 AA Boxmeer, NL)
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