Title:
Anti AQP3 monoclonal antibody specifically binding to extracellular domain of aquaporin 3 (AQP3) and use thereof
Document Type and Number:
WIPO Patent Application WO/2020/213710
Kind Code:
A1
Abstract:
A subject of the present invention is to provide an anti AQP3 antibody specifically recognizing the extracellular domain of aquaporin 3 (AQP3), which is one type of a water channel protein. By selecting a monoclonal antibody which specifically binds to an oligopeptide included in loop C as the extracellular domains of AQP3, anti AQP3 antibodies that are desired in the present invention are provided. An anti AQP3 monoclonal antibody of the present invention can directly bind, from the outside of a cell, to AQP3 present in a cell membrane. Furthermore, as an anti AQP3 monoclonal antibody of the present invention can have an inhibitory activity, the function of permeating a low molecular weight molecule or the like, which is carried by AQP3, can be suppressed.
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Inventors:
CHIKUMA MARIKO (JP)
YASUI MASATO (JP)
YASUI MASATO (JP)
Application Number:
PCT/JP2020/016856
Publication Date:
October 22, 2020
Filing Date:
April 17, 2020
Export Citation:
Assignee:
UNIV KEIO (JP)
International Classes:
C07K16/28; A61K39/395; A61P29/00; A61P37/00
Domestic Patent References:
| WO2019074124A1 | 2019-04-18 | |||
| WO2014013727A1 | 2014-01-23 | |||
| WO2014013727A1 | 2014-01-23 | |||
| WO1998013388A1 | 1998-04-02 | |||
| WO1991009967A1 | 1991-07-11 | |||
| WO2015179360A1 | 2015-11-26 | |||
| WO1998013388A1 | 1998-04-02 |
Foreign References:
| JP2011032191A | 2011-02-17 | |||
| US5530101A | 1996-06-25 | |||
| US5585089A | 1996-12-17 | |||
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VERKMAN ET AL., NAT. REV. DRUG DISCOV., vol. 13, 2014, pages 259 - 277
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IKARASHI ET AL., INT. J. MOL. SCI., vol. 17, 2016, pages 1172
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HARA-CHIKUMA ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 471, 2016, pages 603 - 609
RIECHMANN ET AL., NATURE, vol. 332, 1988, pages 323 - 7
PADLAN, MOL. IMMUNOL., vol. 28, 1991, pages 489 - 498
STUDNICKA ET AL., PROT. ENG., vol. 7, 1994, pages 805 - 814
ROGUSKA ET AL., PROC. NATL. ACAD. SCI., vol. 91, 1994, pages 969 - 973
CANFFELDMORRISON, J. EXP. MED., vol. 173, 1991, pages 1483 - 1491
LUND ET AL., J. IMMUNOL., vol. 147, pages 2657 - 2662
TSUCHIKAMAAN, PROTEIN & CELL, vol. 9, no. 1, 2018, pages 33 - 46
DEONARAIN ET AL., EXPERT OPIN DRUG DISCOV., vol. 10, no. 5, 2015, pages 463 - 81
SINGH ET AL., PHARM RES., vol. 32, no. ll, November 2015 (2015-11-01), pages 3541 - 71
ALLEY ET AL., CURRENT OPINION IN CHEMICAL BIOLOGY, vol. 14, 2010, pages 1 - 9
SENTER, CANCER J., vol. 14, no. 3, 2008, pages 154 - 169
DUBOWCHIKWALKER, PHARM. THERAPEUTICS, vol. 83, 1999, pages 67 - 123
MA ET AL., PNAS, vol. 97, no. 8, 2000, pages 4386 - 4391
LEFRANC ET AL., DEV COMPARAT IMMUNOL, vol. 27, 2003, pages 55 - 77
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, PUBLIC HEALTH SERVICE, NATIONAL INSTITUTES OF HEALTH
AL-LAZIKANI ET AL., J. MOL. BIOL, vol. 273, 1997, pages 927 - 948
YANG C ET AL: "Aquaporin 3 is regulated by estrogen in the chicken oviduct and is involved in progression of epithelial cell-derived ovarian carcinomas", DOMESTIC ANIMAL ENDOCRINOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 55, 23 December 2015 (2015-12-23), pages 97 - 106, XP029450500, ISSN: 0739-7240, DOI: 10.1016/J.DOMANIEND.2015.12.003
YONGMING LI ET AL: "Expression of aquaporin-1 in SMMC-7221 liver carcinoma cells promotes cell migration", CHINESE SCIENCE BULLETIN, SCIENCE IN CHINA PRESS, BE, vol. 51, no. 20, 1 October 2006 (2006-10-01), pages 2466 - 2471, XP019455529, ISSN: 1861-9541, DOI: 10.1007/S11434-006-2147-4
VIECELI DALLA SEGA FRANCESCO ET AL: "Specific aquaporins facilitate Nox-produced hydrogen peroxide transport through plasma membrane in leukaemia cells", BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR CELL RESEARCH, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 1843, no. 4, 16 January 2014 (2014-01-16), pages 806 - 814, XP028665810, ISSN: 0167-4889, DOI: 10.1016/J.BBAMCR.2014.01.011
HIROKI SATOOKA ET AL: "Aquaporin-3 Controls Breast Cancer Cell Migration by Regulating Hydrogen Peroxide Transport and Its Downstream Cell Signaling", MOLECULAR AND CELLULAR BIOLOGY, vol. 36, no. 7, 1 April 2016 (2016-04-01), pages 1206 - 1218, XP055526765, ISSN: 0270-7306, DOI: 10.1128/MCB.00971-15
ANONYMOUS: "AQP3 (H-30): sc-20811", 1 January 2007 (2007-01-01), XP002796288, Retrieved from the Internet
DAVID C. SOLER ET AL: "Overexpression of AQP3 and AQP10 in the skin exacerbates psoriasiform acanthosis", EXPERIMENTAL DERMATOLOGY, vol. 26, no. 10, 21 April 2017 (2017-04-21), COPENHAGEN; DK, pages 949 - 951, XP055650325, ISSN: 0906-6705, DOI: 10.1111/exd.13307
VERKMAN ET AL., NAT. REV. DRUG DISCOV., vol. 13, 2014, pages 259 - 277
HARA-CHIKUMA ET AL., J. INVEST. DERMATOL., vol. 128, 2008, pages 2145 - 2151
PAPADOPOULOSSAADOUN, BIOCHEM. BIOCHIM. ACTA, vol. 1848, 2015, pages 2576 - 2583
WANG ET AL., J. TRANSL. MED., vol. 13, 2015, pages 96
IKARASHI ET AL., INT. J. MOL. SCI., vol. 17, 2016, pages 1172
ZELENINA ET AL., J. BIOL. CHEM., vol. 279, 2004, pages 51939 - 51943
MARTINS ET AL., PLOS ONE, vol. 7, no. 5, 2012, pages e37435
HARA-CHIKUMA ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 471, 2016, pages 603 - 609
RIECHMANN ET AL., NATURE, vol. 332, 1988, pages 323 - 7
PADLAN, MOL. IMMUNOL., vol. 28, 1991, pages 489 - 498
STUDNICKA ET AL., PROT. ENG., vol. 7, 1994, pages 805 - 814
ROGUSKA ET AL., PROC. NATL. ACAD. SCI., vol. 91, 1994, pages 969 - 973
CANFFELDMORRISON, J. EXP. MED., vol. 173, 1991, pages 1483 - 1491
LUND ET AL., J. IMMUNOL., vol. 147, pages 2657 - 2662
TSUCHIKAMAAN, PROTEIN & CELL, vol. 9, no. 1, 2018, pages 33 - 46
DEONARAIN ET AL., EXPERT OPIN DRUG DISCOV., vol. 10, no. 5, 2015, pages 463 - 81
SINGH ET AL., PHARM RES., vol. 32, no. ll, November 2015 (2015-11-01), pages 3541 - 71
ALLEY ET AL., CURRENT OPINION IN CHEMICAL BIOLOGY, vol. 14, 2010, pages 1 - 9
SENTER, CANCER J., vol. 14, no. 3, 2008, pages 154 - 169
DUBOWCHIKWALKER, PHARM. THERAPEUTICS, vol. 83, 1999, pages 67 - 123
MA ET AL., PNAS, vol. 97, no. 8, 2000, pages 4386 - 4391
LEFRANC ET AL., DEV COMPARAT IMMUNOL, vol. 27, 2003, pages 55 - 77
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, PUBLIC HEALTH SERVICE, NATIONAL INSTITUTES OF HEALTH
AL-LAZIKANI ET AL., J. MOL. BIOL, vol. 273, 1997, pages 927 - 948
Attorney, Agent or Firm:
SAEKI, Takuro et al. (JP)
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