Title:
ANTI-HER2/CD3 BISPECIFIC ANTIBODY SPECIFICALLY ACTIVATED IN TUMOR MICROENVIRONMENT
Document Type and Number:
WIPO Patent Application WO/2024/041435
Kind Code:
A1
Abstract:
The present invention relates to an anti-Her2/CD3 bispecific antibody specifically activated in a tumor microenvironment. Specifically, provided is a bispecific antibody capable of being chemically conjugated to a substrate that is highly expressed in a tumor environment and can be recognized and cut, as well as a masking moiety, in a chemical coupling manner. The antibody activity of the bispecific antibody of the present invention in normal tissues is suppressed, but is activated in a tumor environment. In addition, the bispecific antibody of the present invention also has significantly reduced toxicity.
Inventors:
DING CHENGLI (CN)
LIU YUAN (CN)
LIU CHEN (CN)
LIU YUAN (CN)
LIU CHEN (CN)
Application Number:
PCT/CN2023/113380
Publication Date:
February 29, 2024
Filing Date:
August 16, 2023
Export Citation:
Assignee:
YING MAI DE MEDICAL TECH GUANGDONG CO LTD (CN)
International Classes:
C07K16/28; A61K39/395; A61P35/00; C12N5/10; C12N15/13; C12N15/63
Foreign References:
| CN113015749A | 2021-06-22 | |||
| CN107722124A | 2018-02-23 | |||
| CN110551221A | 2019-12-10 | |||
| CN112794916A | 2021-05-14 | |||
| CN112867735A | 2021-05-28 | |||
| CN113461821A | 2021-10-01 | |||
| US9587021B2 | 2017-03-07 |
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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