Title:
ANTI-CANCER AGENT COMPRISING HVJ-E AND CXCL2
Document Type and Number:
WIPO Patent Application WO/2017/033912
Kind Code:
A1
Abstract:
The present invention provides an anti-cancer agent, as a novel anti-cancer agent that is obtained by combining HVJ-E with a molecule that acts synergistically with the HVJ-E, the anti-cancer agent including the following (1) and (2): (1) HVJ-E (hemagglutinating virus of Japan envelope); and (2) CXCL2, a nucleic acid comprising the base sequence encoding CXCL2 or a CXCL2-expression inducer.
Inventors:
KANEDA YASUFUMI (JP)
NAKAJIMA TOSHIHIRO (JP)
NAKAJIMA TOSHIHIRO (JP)
Application Number:
PCT/JP2016/074464
Publication Date:
March 02, 2017
Filing Date:
August 23, 2016
Export Citation:
Assignee:
UNIV OSAKA (JP)
GENOMIDEA INC (JP)
GENOMIDEA INC (JP)
International Classes:
A61K48/00; A61K31/7088; A61K31/713; A61K31/739; A61K35/76; A61K38/19; A61K45/00; A61P35/00
Other References:
KAWAGUCHI YOSHIFUMI ET AL.: "Efficient eradication of hormone-resistant human prostate cancers by inactivated Sendai virus particle", INTERNATIONAL JOURNAL OF CANCER, vol. 124, no. 10, 2009, pages 2478 - 87, XP055515585
MASAKI NAKAHARA ET AL.: "Effect of Lipopolysaccharide from Proteusmirabilis, alone or with Antitumor Agents, against Experimental Animal Tumors", AGRICULTURAL AND BIOLOGICAL CHEMISTRY, vol. 40, no. 6, 1976, pages 1201 - 1208, XP055372602
TSUTSUMI Y. ET AL.: "Molecular design of hybrid tumour necrosis factor alpha with polyethylene glycol increases its anti-tumour potency", BRITISH JOURNAL OF CANCER, vol. 71, no. 5, 1995, pages 963 - 968, XP009006142
DON D. MICKEY ET AL.: "Effects of the immunomodulator PSK on growth of human prostate adenocarcinoma in immunodeficient mice", INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, vol. 11, no. 7, 1989, pages 829 - 38, XP023812513, DOI: doi:10.1016/0192-0561(89)90137-9
ZVI G. FRIDLENDER ET AL.: "Polarization of tumor-associated neutrophil phenotype by TGF- beta: ''N1'' versus ''N2'' TAN", CANCER CELL, vol. 16, no. 3, 2009, pages 183 - 94, XP055372607
MASAKI NAKAHARA ET AL.: "Effect of Lipopolysaccharide from Proteusmirabilis, alone or with Antitumor Agents, against Experimental Animal Tumors", AGRICULTURAL AND BIOLOGICAL CHEMISTRY, vol. 40, no. 6, 1976, pages 1201 - 1208, XP055372602
TSUTSUMI Y. ET AL.: "Molecular design of hybrid tumour necrosis factor alpha with polyethylene glycol increases its anti-tumour potency", BRITISH JOURNAL OF CANCER, vol. 71, no. 5, 1995, pages 963 - 968, XP009006142
DON D. MICKEY ET AL.: "Effects of the immunomodulator PSK on growth of human prostate adenocarcinoma in immunodeficient mice", INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, vol. 11, no. 7, 1989, pages 829 - 38, XP023812513, DOI: doi:10.1016/0192-0561(89)90137-9
ZVI G. FRIDLENDER ET AL.: "Polarization of tumor-associated neutrophil phenotype by TGF- beta: ''N1'' versus ''N2'' TAN", CANCER CELL, vol. 16, no. 3, 2009, pages 183 - 94, XP055372607
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
Download PDF: