Title:
ANTI-CD28 ANTIBODY
Document Type and Number:
WIPO Patent Application WO2002051871
Kind Code:
A3
Abstract:
The invention concerns an antibody directed against the CD28 receptor and capable of blocking CD28/B7 interaction, and proteins derived from said antibody, for use in particular to block CD28-dependent activation of lymphocytes.
Inventors:
SOULILLOU JEAN-PAUL (FR)
LAFLAMME GENEVIEVE (FR)
VANHOVE BERNARD (FR)
LAFLAMME GENEVIEVE (FR)
VANHOVE BERNARD (FR)
Application Number:
PCT/FR2001/004203
Publication Date:
August 15, 2002
Filing Date:
December 26, 2001
Export Citation:
Assignee:
INST NAT SANTE RECH MED (FR)
SOULILLOU JEAN-PAUL (FR)
LAFLAMME GENEVIEVE (FR)
VANHOVE BERNARD (FR)
SOULILLOU JEAN-PAUL (FR)
LAFLAMME GENEVIEVE (FR)
VANHOVE BERNARD (FR)
International Classes:
A61K38/00; A61K39/395; A61P29/00; A61P37/06; A61P37/08; C07K16/28; C07K16/46; C07K19/00; C12N15/09; C12N5/10; C12P21/02; (IPC1-7): C07K16/28; C12N15/13; C12N15/63; C12N5/20; A61K39/395; A61P37/06; A61P37/08; A61P29/00
Domestic Patent References:
| WO1994028912A1 | 1994-12-22 |
Foreign References:
| EP0440373A1 | 1991-08-07 |
Other References:
TAN P. ET AL.: "Humanization of an anti-CD28 antibody using germline human antibody sequences.", BLOOD (2000 NOV) 96 (11 PART 1) 31A., XP002177441
NUNES J ET AL: "CD28 mAbs with distinct binding properties differ in their ability to induce T cell activation: analysis of early and late activation events.", INTERNATIONAL IMMUNOLOGY, (1993 MAR) 5 (3) 311-5., XP001024214
GILLILAND L. K. ET AL.: "Rapid and reliable cloning of antibody variable regions and generation of recombinant single chain antibody fragments.", TISSUE ANTIGENS, (1996) 47 (1) 1-20., XP000574883
HASPOT FABIENNE ET AL: "Differential effect of CD28 versus B7 blockade on direct pathway of allorecognition and self-restricted responses.", BLOOD. UNITED STATES 15 MAR 2002, vol. 99, no. 6, 15 March 2002 (2002-03-15), pages 2228 - 2234, XP002201786, ISSN: 0006-4971
NUNES J ET AL: "CD28 mAbs with distinct binding properties differ in their ability to induce T cell activation: analysis of early and late activation events.", INTERNATIONAL IMMUNOLOGY, (1993 MAR) 5 (3) 311-5., XP001024214
GILLILAND L. K. ET AL.: "Rapid and reliable cloning of antibody variable regions and generation of recombinant single chain antibody fragments.", TISSUE ANTIGENS, (1996) 47 (1) 1-20., XP000574883
HASPOT FABIENNE ET AL: "Differential effect of CD28 versus B7 blockade on direct pathway of allorecognition and self-restricted responses.", BLOOD. UNITED STATES 15 MAR 2002, vol. 99, no. 6, 15 March 2002 (2002-03-15), pages 2228 - 2234, XP002201786, ISSN: 0006-4971
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