Title:
ANTI-CD39 ANTIBODIES AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/164872
Kind Code:
A1
Abstract:
Provided herein are anti-CD39 antibodies that inhibit the enzymatic activity of human CD39 and methods of using the same
Inventors:
BOWMAN CHRISTINE ELIZABETH (US)
CHEN ADA PEI XIAN (US)
FERNANDEZ-SALAS ESTER (US)
WALKER NIGEL PELHAM CLINTON (US)
ZHAO XIAONING (US)
HU YAOHUA (CN)
NIE SIWEI (CN)
GU JIJIE (CN)
CHEN ADA PEI XIAN (US)
FERNANDEZ-SALAS ESTER (US)
WALKER NIGEL PELHAM CLINTON (US)
ZHAO XIAONING (US)
HU YAOHUA (CN)
NIE SIWEI (CN)
GU JIJIE (CN)
Application Number:
PCT/CN2022/079021
Publication Date:
September 07, 2023
Filing Date:
March 03, 2022
Export Citation:
Assignee:
ARCUS BIOSCIENCES INC (US)
WUXI BIOLOGICS SHANGHAI CO LTD (CN)
WUXI BIOLOGICS IRELAND LTD (IE)
WUXI BIOLOGICS SHANGHAI CO LTD (CN)
WUXI BIOLOGICS IRELAND LTD (IE)
International Classes:
A61K39/00; C07K16/28; A61K39/395; C12N5/10; C12N15/13; C12N15/62; C12N15/63
Domestic Patent References:
| WO2009095478A1 | 2009-08-06 |
Foreign References:
| CN113754768A | 2021-12-07 | |||
| CN111448211A | 2020-07-24 | |||
| US20210363268A1 | 2021-11-25 | |||
| CN112262155A | 2021-01-22 | |||
| SG11202008390SA | 2020-09-29 |
Other References:
XIAN-YANG LI, ACHIM K. MOESTA, CHRISTOS XIAO, KYOHEI NAKAMURA, MIKA CASEY, HAIYAN ZHANG, JASON MADORE, AILIN LEPLETIER, AMELIA ROM: "Targeting CD39 in Cancer Reveals an Extracellular ATP- and Inflammasome-Driven Tumor Immunity", CANCER DISCOVERY, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 9, no. 12, 1 December 2019 (2019-12-01), US , pages 1754 - 1773, XP055700762, ISSN: 2159-8274, DOI: 10.1158/2159-8290.CD-19-0541
SPATOLA BRADLEY N., LERNER ALANA G., WONG CLIFFORD, DELA CRUZ TRACY, WELCH MEGAN, FUNG WANCHI, KOVALENKO MARIA, LOSENKOVA KAROLINA: "Fully human anti-CD39 antibody potently inhibits ATPase activity in cancer cells via uncompetitive allosteric mechanism", MABS, LANDES BIOSCIENCE, US, vol. 12, no. 1, 1 January 2020 (2020-01-01), US , XP093073023, ISSN: 1942-0862, DOI: 10.1080/19420862.2020.1838036
SPATOLA BRADLEY N., LERNER ALANA G., WONG CLIFFORD, DELA CRUZ TRACY, WELCH MEGAN, FUNG WANCHI, KOVALENKO MARIA, LOSENKOVA KAROLINA: "Fully human anti-CD39 antibody potently inhibits ATPase activity in cancer cells via uncompetitive allosteric mechanism", MABS, LANDES BIOSCIENCE, US, vol. 12, no. 1, 1 January 2020 (2020-01-01), US , XP093073023, ISSN: 1942-0862, DOI: 10.1080/19420862.2020.1838036
Attorney, Agent or Firm:
WU, FENG & ZHANG (CN)
Download PDF: