Title:
ANTI-CDH3 HUMANIZED ANTIBODY, DRUG CONJUGATE THEREOF, AND UTILIZATION OF SAME
Document Type and Number:
WIPO Patent Application WO/2014/126198
Kind Code:
A1
Abstract:
The present invention addresses the problem of producing an anti-CDH3 humanized antibody having lower immunogenicity and provide an anti-CDH3 humanized antibody-drug conjugate using the same, said anti-CDH3 humanized antibody-drug conjugate being capable of more efficiently killing CDH3-expressing cancer cells. Provided is an anti-CDH3 humanized antibody-drug conjugate produced by linking an anti-CDH3 humanized antibody to a cytotoxic drug, wherein: the anti-CDH3 humanized antibody comprises complementarity determining region sequences originated from the heavy chain variable region of an antibody that is produced by a cell (Deposition No. NITE BP-1536) and complementarity determining region sequences originated from the light chain variable region thereof; the framework region sequences in the heavy chain variable region comprise a heavy chain human subgroup III consensus framework sequence or a human germ line sequence selected at the optimum alignment; and the framework region sequences in the light chain variable region include a light chain human κ subgroup I consensus framework sequence or a human germ line sequence selected at the optimum alignment.
Inventors:
ISHII KEISUKE (JP)
MITOMO KATSUYUKI (JP)
KOUDA KATSUSHI (JP)
NOMURA FUMIKO (JP)
KAYUKAWA YOKO (JP)
MATSUURA TADASHI (JP)
MITOMO KATSUYUKI (JP)
KOUDA KATSUSHI (JP)
NOMURA FUMIKO (JP)
KAYUKAWA YOKO (JP)
MATSUURA TADASHI (JP)
Application Number:
PCT/JP2014/053473
Publication Date:
August 21, 2014
Filing Date:
February 14, 2014
Export Citation:
Assignee:
PERSEUS PROTEOMICS INC (JP)
International Classes:
C12N15/09; A61K39/395; A61P35/00; C07K16/28; C07K16/46
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NATURE, vol. 332, 1988, pages 323
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CANCER RES., vol. 68, no. 22, 2008, pages 9280
NATURE BIOTECHNOLOGY, vol. 26, no. 8, 2008, pages 925
BIO CONJUGATE CHEMISTRY, vol. 19, 2008, pages 1673
CANCER RES., vol. 68, no. 15, 2008, pages 6300
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J. MED. CHEM., vol. 49, 2006, pages 4392
CANCER RES., vol. 52, 1992, pages 127
JOURNAL OF IMMUNOLOGY, vol. 169, 2002, pages 1119
"Sequences of proteins of immunological interest, 5th ed.", 1991, NATIONAL INSTITUTES OF HEALTH
J. MOL BIOL., vol. 196, 1987, pages 901
J. IMMUNOL., vol. 151, 1993, pages 2296
J. MOL. BIOL., vol. 196, 1987, pages 901
BIOTECHNOLOGY, vol. 9, 1991, pages 266
PROC. NATL. ACAD. SCI. USA, vol. 89, 1992, pages 4285
METHODS. MOL. BIOL., vol. 525, 2009, pages 445
KABAT ET AL.: "Sequences of proteins of immunological interest, 5th ed.", 1991, NATIONAL INSTITUTES OF HEALTH
CHOTHIA ET AL., J. MOL. BIOL., vol. 196, 1987, pages 901
SIMS ET AL., J. IMMUNOL., vol. 151, 1993, pages 2296
TEMPEST ET AL., BIOTECHNOLOGY, vol. 9, 1991, pages 266
PROC. NATL. ACAD. SCI. U.S.A., vol. 89, 1992, pages 4285
URLAND, G. ET AL., SOMAT. CELL. MOL. GENET., vol. 12, 1986, pages 5555
SCHULMAN, M. ET AL., NATURE, vol. 276, 1978, pages 269
"Current Protocols in Molecular Biology", JOHN WILEY AND SONS, INC., article "Chapter 9 Introduction of DNA into Mammalian Cells"
ANALYTICAL BIOCHEMISTY, vol. 173, 1988, pages 93 - 95
"Current Protocols in Immunology", JOHN WILEY AND SONS, INC., article "Unit 2.12 Cloning, Expression, and Modification of Antibody V Regions"
TAN ET AL., JOURNAL OF IMMUNOLOGY, vol. 169, 2002, pages 1119
J. MED. CHEM., vol. 49, 2006, pages 4392 - 4408
METHODS. MOL. BIOL., vol. 525, 2009, pages 445 - 67
See also references of EP 2957632A4
YOSHIDA; TAKEICHI, CELL, vol. 28, 1982, pages 217 - 224
N. ENGL. J. MED., vol. 367, no. 19, 8 November 2012 (2012-11-08), pages 1783 - 91
NATURE, vol. 332, 1988, pages 323
N. ENGL. J. MED, vol. 367, no. 19, 8 November 2012 (2012-11-08), pages 1783 - 91
SOMAT. CELL. MOL. GENET, vol. 12, 1986, pages 5555
NATURE, vol. 276, 1978, pages 269
CANCER RES., vol. 68, no. 22, 2008, pages 9280
NATURE BIOTECHNOLOGY, vol. 26, no. 8, 2008, pages 925
BIO CONJUGATE CHEMISTRY, vol. 19, 2008, pages 1673
CANCER RES., vol. 68, no. 15, 2008, pages 6300
ANALYTICAL BIOCHEMISTY, vol. 173, 1988, pages 93
"Phage Display - A Laboratory Manual", ., article "PROTOCOL 9.5"
J. MED. CHEM., vol. 49, 2006, pages 4392
CANCER RES., vol. 52, 1992, pages 127
JOURNAL OF IMMUNOLOGY, vol. 169, 2002, pages 1119
"Sequences of proteins of immunological interest, 5th ed.", 1991, NATIONAL INSTITUTES OF HEALTH
J. MOL BIOL., vol. 196, 1987, pages 901
J. IMMUNOL., vol. 151, 1993, pages 2296
J. MOL. BIOL., vol. 196, 1987, pages 901
BIOTECHNOLOGY, vol. 9, 1991, pages 266
PROC. NATL. ACAD. SCI. USA, vol. 89, 1992, pages 4285
METHODS. MOL. BIOL., vol. 525, 2009, pages 445
KABAT ET AL.: "Sequences of proteins of immunological interest, 5th ed.", 1991, NATIONAL INSTITUTES OF HEALTH
CHOTHIA ET AL., J. MOL. BIOL., vol. 196, 1987, pages 901
SIMS ET AL., J. IMMUNOL., vol. 151, 1993, pages 2296
TEMPEST ET AL., BIOTECHNOLOGY, vol. 9, 1991, pages 266
PROC. NATL. ACAD. SCI. U.S.A., vol. 89, 1992, pages 4285
URLAND, G. ET AL., SOMAT. CELL. MOL. GENET., vol. 12, 1986, pages 5555
SCHULMAN, M. ET AL., NATURE, vol. 276, 1978, pages 269
"Current Protocols in Molecular Biology", JOHN WILEY AND SONS, INC., article "Chapter 9 Introduction of DNA into Mammalian Cells"
ANALYTICAL BIOCHEMISTY, vol. 173, 1988, pages 93 - 95
"Current Protocols in Immunology", JOHN WILEY AND SONS, INC., article "Unit 2.12 Cloning, Expression, and Modification of Antibody V Regions"
TAN ET AL., JOURNAL OF IMMUNOLOGY, vol. 169, 2002, pages 1119
J. MED. CHEM., vol. 49, 2006, pages 4392 - 4408
METHODS. MOL. BIOL., vol. 525, 2009, pages 445 - 67
See also references of EP 2957632A4
Attorney, Agent or Firm:
SIKs & Co. (JP)
Patent business corporation patent firm Sykes (JP)
Patent business corporation patent firm Sykes (JP)
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