Title:
ANTI-CRYPTOSPORIDIUM DRUG AND METHOD FOR PREVENTING OR TREATING CRYPTOSPORIDIOSIS
Document Type and Number:
WIPO Patent Application WO/2023/228257
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a novel anti-cryptosporidium drug. The present invention provides an anti-cryptosporidium drug containing at least one selected from the group consisting of bufotalin, cinobufotalin, atropine and salts thereof.
Inventors:
KATO KENTARO (JP)
BIN KABIR MD HAZZAZ (JP)
BIN KABIR MD HAZZAZ (JP)
Application Number:
PCT/JP2022/021139
Publication Date:
November 30, 2023
Filing Date:
May 23, 2022
Export Citation:
Assignee:
UNIV TOHOKU (JP)
International Classes:
A61K31/585; A61K31/46; A61P33/02
Domestic Patent References:
| WO2017217071A1 | 2017-12-21 |
Foreign References:
| JP2020180100A | 2020-11-05 | |||
| US20060205679A1 | 2006-09-14 |
Other References:
RODRIGUEZ CANDELARIO, IBÁÑEZ ROBERTO, MOJICA LUIS, NG MICHELLE, SPADAFORA CARMENZA, DURANT-ARCHIBOLD ARMANDO A., GUTIÉRREZ MARCELI: "Bufadienolides from the Skin Secretions of the Neotropical Toad Rhinella alata (Anura: Bufonidae): Antiprotozoal Activity against Trypanosoma cruzi", MOLECULES, MDPI AG, CH, vol. 26, no. 14, CH , pages 4217, XP093111681, ISSN: 1420-3049, DOI: 10.3390/molecules26144217
BANFI FELIPE FINGER, GUEDES KARLA DE SENA, ANDRIGHETTI CARLA REGINA, AGUIAR ANA CAROLINA, DEBIASI BRYAN WENDER, NORONHA JANAINA DA: "Antiplasmodial and Cytotoxic Activities of Toad Venoms from Southern Amazon, Brazil", KOREAN JOURNAL OF PARASITOLOGY., SEOUL., KR, vol. 54, no. 4, KR , pages 415 - 421, XP093111689, ISSN: 0023-4001, DOI: 10.3347/kjp.2016.54.4.415
SCHMEDA-HIRSCHMANN GUILLERMO; GOMEZ CELESTE VEGA; ROJAS DE ARIAS ANTONIETA; BURGOS-EDWARDS ALBERTO; ALFONSO JORGE; ROLON MIRIAM; B: "The ParaguayanRhinellatoad venom: Implications in the traditional medicine and proliferation of breast cancer cells", JOURNAL OF ETHNOPHARMACOLOGY, ELSEVIER IRELAND LTD, IE, vol. 199, 25 January 2017 (2017-01-25), IE , pages 106 - 118, XP029940023, ISSN: 0378-8741, DOI: 10.1016/j.jep.2017.01.047
MEDEIROS DANIEL S. S. DE, REGO TIAGO B., SANTOS ANA P. DE A. DOS, PONTES ADRIANA S., MOREIRA-DILL LEANDRO S., MATOS NAJLA B., ZULI: "Biochemical and Biological Profile of Parotoid Secretion of the Amazonian Rhinella marina (Anura: Bufonidae)", BIOMED RESEARCH INTERNATIONAL, HINDAWI PUBLISHING CORPORATION, vol. 2019, 21 February 2019 (2019-02-21), pages 1 - 15, XP093111692, ISSN: 2314-6133, DOI: 10.1155/2019/2492315
ADEYEMI OLUYOMI STEPHEN, ATOLANI OLUBUNMI, AWAKAN OLUWAKEMI JOSEPHINE, OLAOLU TOMILOLA DEBBY, NWONUMA CHARLES OBIORA, ALEJOLOWO OM: "In Vitro Screening to Identify Anti- Toxoplasma Compounds and In Silico Modeling for Bioactivities and Toxicity", THE YALE JOURNAL OF BIOLOGY AND MEDICINE, YALE JOURNAL OF BIOLOGY AND MEDICINE, US, vol. 92, no. 3, 1 September 2019 (2019-09-01), US , pages 369 - 383, XP093111696, ISSN: 0044-0086
SINHORIN ADILSON PAULO; KERKHOFF JACQUELINE; DALLOGLIO EVADRO LUIZ; DE JESUS RODRIGUES DOMINGOS; DE VASCONCELOS LEONARDO GOM: "Chemical profile of the parotoid gland secretion of the Amazonian toad (Rhinella margaritifera)", TOXICON, ELMSFORD, NY, US, vol. 182, 6 May 2020 (2020-05-06), US , pages 30 - 33, XP086171943, ISSN: 0041-0101, DOI: 10.1016/j.toxicon.2020.04.106
OLIVEIRA RAQUEL SOARES, BORGES BRUNA TRINDADE, LEAL ALLAN PINTO, LAILOWSKI MANUELA MERLIN, BORDON KARLA DE CASTRO FIGUEIREDO, SOUZ: "Chemical and Pharmacological Screening of Rhinella icterica (Spix 1824) Toad Parotoid Secretion in Avian Preparations", TOXINS, MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL (MDPI) AG., CH, vol. 12, no. 6, CH , pages 396, XP093111701, ISSN: 2072-6651, DOI: 10.3390/toxins12060396
BANFI FELIPE FINGER, GUEDES KARLA DE SENA, ANDRIGHETTI CARLA REGINA, AGUIAR ANA CAROLINA, DEBIASI BRYAN WENDER, NORONHA JANAINA DA: "Antiplasmodial and Cytotoxic Activities of Toad Venoms from Southern Amazon, Brazil", KOREAN JOURNAL OF PARASITOLOGY., SEOUL., KR, vol. 54, no. 4, KR , pages 415 - 421, XP093111689, ISSN: 0023-4001, DOI: 10.3347/kjp.2016.54.4.415
SCHMEDA-HIRSCHMANN GUILLERMO; GOMEZ CELESTE VEGA; ROJAS DE ARIAS ANTONIETA; BURGOS-EDWARDS ALBERTO; ALFONSO JORGE; ROLON MIRIAM; B: "The ParaguayanRhinellatoad venom: Implications in the traditional medicine and proliferation of breast cancer cells", JOURNAL OF ETHNOPHARMACOLOGY, ELSEVIER IRELAND LTD, IE, vol. 199, 25 January 2017 (2017-01-25), IE , pages 106 - 118, XP029940023, ISSN: 0378-8741, DOI: 10.1016/j.jep.2017.01.047
MEDEIROS DANIEL S. S. DE, REGO TIAGO B., SANTOS ANA P. DE A. DOS, PONTES ADRIANA S., MOREIRA-DILL LEANDRO S., MATOS NAJLA B., ZULI: "Biochemical and Biological Profile of Parotoid Secretion of the Amazonian Rhinella marina (Anura: Bufonidae)", BIOMED RESEARCH INTERNATIONAL, HINDAWI PUBLISHING CORPORATION, vol. 2019, 21 February 2019 (2019-02-21), pages 1 - 15, XP093111692, ISSN: 2314-6133, DOI: 10.1155/2019/2492315
ADEYEMI OLUYOMI STEPHEN, ATOLANI OLUBUNMI, AWAKAN OLUWAKEMI JOSEPHINE, OLAOLU TOMILOLA DEBBY, NWONUMA CHARLES OBIORA, ALEJOLOWO OM: "In Vitro Screening to Identify Anti- Toxoplasma Compounds and In Silico Modeling for Bioactivities and Toxicity", THE YALE JOURNAL OF BIOLOGY AND MEDICINE, YALE JOURNAL OF BIOLOGY AND MEDICINE, US, vol. 92, no. 3, 1 September 2019 (2019-09-01), US , pages 369 - 383, XP093111696, ISSN: 0044-0086
SINHORIN ADILSON PAULO; KERKHOFF JACQUELINE; DALLOGLIO EVADRO LUIZ; DE JESUS RODRIGUES DOMINGOS; DE VASCONCELOS LEONARDO GOM: "Chemical profile of the parotoid gland secretion of the Amazonian toad (Rhinella margaritifera)", TOXICON, ELMSFORD, NY, US, vol. 182, 6 May 2020 (2020-05-06), US , pages 30 - 33, XP086171943, ISSN: 0041-0101, DOI: 10.1016/j.toxicon.2020.04.106
OLIVEIRA RAQUEL SOARES, BORGES BRUNA TRINDADE, LEAL ALLAN PINTO, LAILOWSKI MANUELA MERLIN, BORDON KARLA DE CASTRO FIGUEIREDO, SOUZ: "Chemical and Pharmacological Screening of Rhinella icterica (Spix 1824) Toad Parotoid Secretion in Avian Preparations", TOXINS, MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL (MDPI) AG., CH, vol. 12, no. 6, CH , pages 396, XP093111701, ISSN: 2072-6651, DOI: 10.3390/toxins12060396
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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