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Title:
ANTI-DR5 ANTIBODY AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/100194
Kind Code:
A1
Abstract:
Disclosed are an anti-DR5 antibody and a preparation method therefor and the use thereof. The antibody comprises a constant region and a variable region, wherein the heavy chain variable region comprises CDR1 as shown in SEQ ID NO: 1, CDR2 as shown in SEQ ID NO: 2 and CDR3 as shown in SEQ ID NO: 3; the light chain variable region comprises CDR1' as shown in SEQ ID NO: 4, CDR2' as shown in SEQ ID NO: 5 and CDR3' as shown in SEQ ID NO: 6. The antibody can specifically bind to the antigen DR5 but has no cross reaction with DR4, has a very high affinity and biological activity, can induce apoptosis without the addition of crosslinking agents, and can synergistically induce apoptosis in combination with TRAIL.

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Inventors:
WAN XIAOCHUN (CN)
CHEN QIAN (CN)
XIA MENG (CN)
LI JUNXIN (CN)
LIU LVYAN (CN)
ZHANG QINGMEI (CN)
Application Number:
PCT/CN2017/112073
Publication Date:
May 31, 2019
Filing Date:
November 21, 2017
Export Citation:
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Assignee:
SHENZHEN INST ADV TECH (CN)
International Classes:
C07K16/28; A61K39/395; A61P35/00; C12N15/13; C12N15/63
Domestic Patent References:
WO2001083560A12001-11-08
Foreign References:
CN101247825A2008-08-20
CN106397594A2017-02-15
CN103282495A2013-09-04
Attorney, Agent or Firm:
HENSEN INTELLECTUAL PROPERTY FIRM (CN)
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