Title:
ANTI-HLA-DQ2.5 ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2019/069993
Kind Code:
A1
Abstract:
The antibodies of the present invention have specific binding activity to HLA-DQ2.5 and may have binding activity to HLA-DQ2.2 and/or HLA-DQ7.5, but substantially no binding activity to HLA-DQ8, HLA-DQ5.1, HLA-DQ6.3, HLA-DQ7.3, HLA-DR, HLA-DP, or a complex of the invariant chain (CD74) and HLA-DQ2.5. The antibodies bind to HLA-DQ2.5 in the presence of a gluten peptide such as gliadin, i.e., bind to HLA-DQ2.5 forming a complex with the gluten peptide. The antibodies have neutralizing activity against the binding between HLA-DQ2.5 and TCR, and thus block the interaction between HLA-DQ2.5 and an HLA-DQ2.5-restricted CD4+ T cell. The antibodies do not undergo rapid internalization mediated by the invariant chain.
Inventors:
OKURA YUU (SG)
TAKAHASHI NORIYUKI (SG)
TSUSHIMA TAKASHI (SG)
HARFUDDIN ZULKARNAIN (SG)
TAKAHASHI NORIYUKI (SG)
TSUSHIMA TAKASHI (SG)
HARFUDDIN ZULKARNAIN (SG)
Application Number:
PCT/JP2018/037078
Publication Date:
April 11, 2019
Filing Date:
October 03, 2018
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
C07K16/28; C12N15/11
Domestic Patent References:
| WO2010141658A1 | 2010-12-09 | |||
| WO2018155692A1 | 2018-08-30 |
Other References:
ANDERSON R P. ET AL.: "T cells in peripheral blood after gluten challenge in coeliac disease", GUT, vol. 54, 2005, pages 1217 - 1223, XP009060203, DOI: doi:10.1136/gut.2004.059998
DU PRE MF. ET AL.: "Tolerance to Ingested Deamidated Gliadin in Mice is Maintained by Splenic, Type 1 Regulatory T cells", GASTROENTEROLOGY, vol. 141, 2011, pages 610 - 620, XP028253746
MOLDENHAUER G. ET AL.: "Surface-expressed invariant chain ( CD 74) is required for internalization of human leucocyte antigen-DR molecules to early endosomal compartments", IMMUNOLOGY, vol. 96, 1999, pages 473 - 484, XP055590649
STEIN R ET AL.: "CD 74: A New Candidate Target for the Immunotherapy of B- cell Neoplasms", CLIN CANCER RES, vol. 13, no. 18, 2007, pages 5556s - 5563s, XP002510850, DOI: doi:10.1158/1078-0432.CCR-07-1167
See also references of EP 3692072A4
DU PRE MF. ET AL.: "Tolerance to Ingested Deamidated Gliadin in Mice is Maintained by Splenic, Type 1 Regulatory T cells", GASTROENTEROLOGY, vol. 141, 2011, pages 610 - 620, XP028253746
MOLDENHAUER G. ET AL.: "Surface-expressed invariant chain ( CD 74) is required for internalization of human leucocyte antigen-DR molecules to early endosomal compartments", IMMUNOLOGY, vol. 96, 1999, pages 473 - 484, XP055590649
STEIN R ET AL.: "CD 74: A New Candidate Target for the Immunotherapy of B- cell Neoplasms", CLIN CANCER RES, vol. 13, no. 18, 2007, pages 5556s - 5563s, XP002510850, DOI: doi:10.1158/1078-0432.CCR-07-1167
See also references of EP 3692072A4
Attorney, Agent or Firm:
HARUNA, Masao et al. (JP)
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