Title:
ANTI-HUMAN FN14 ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2020/090892
Kind Code:
A1
Abstract:
[Problem] To provide an anti-human Fn14 antibody that binds to human Fn14 and blocks action mediated through human Fn14 to prevent or treat cancer cachexia. [Solution] The present inventors conducted research on anti-human Fn14 antibodies, and have provided an anti-human Fn14 antibody including a heavy chain having the amino acid sequence of SEQ ID NO: 2 and a light chain having the amino acid sequence of SEQ ID NO: 4.
Inventors:
ITO MISATO (JP)
KASHIWAGI RISA (JP)
KAWAKAMI MASAKATSU (JP)
KASHIWAGI RISA (JP)
KAWAKAMI MASAKATSU (JP)
Application Number:
PCT/JP2019/042587
Publication Date:
May 07, 2020
Filing Date:
October 30, 2019
Export Citation:
Assignee:
ASTELLAS PHARMA INC (JP)
International Classes:
A61K39/395; A61P35/00; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/13; C12N15/63; C12P21/08
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| WO2009020933A2 | 2009-02-12 | |||
| WO2013026099A1 | 2013-02-28 | |||
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Foreign References:
| JP2014529597A | 2014-11-13 | |||
| JP2016521715A | 2016-07-25 | |||
| JP2014510079A | 2014-04-24 | |||
| JP2011523414A | 2011-08-11 | |||
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| JP2008531746A | 2008-08-14 | |||
| US6596541B2 | 2003-07-22 |
Other References:
SALZMANN, S. ET AL.: "Fibroblast Growth Factor Inducible (Fnl4)-specific Antibodies Concomitantly Display Signaling Pathway-specific Agonistic and Antagonistic Activity", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 288, no. 19, 2013, pages 13455 - 13466, XP002729800, DOI: 10.1074/jbc.M112.435917
EVANS WJ ET AL., CLIN NUTR., vol. 27, 2008, pages 793 - 799
BARACOS VE ET AL., NAT REV DIS PRIMERS, vol. 4, 2018, pages 1 - 18
WINKLES JA, NAT REV DRUG DISCOV., vol. 7, 2008, pages 411 - 425
CULP PA ET AL., CLIN CANCER RES., vol. 16, 2010, pages 497 - 508
HU G ET AL., TUMOR BIOL., vol. 39, June 2017 (2017-06-01), pages 1 - 9
JOHNSTON AJ ET AL., CELL, vol. 162, 2015, pages 1365 - 1378
LAM ET ET AL., MOL CANCER THER., vol. 17, 2018, pages 215 - 221
CHOI D ET AL., AM J PHARMACOL TOXICOL., vol. 12, 2017, pages 18 - 38
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, UNITED STATES PUBLIC HEALTH SERVICE, NATIONAL INSTITUTE OF HEALTH
LIU H ET AL., J PHAR SCI., vol. 97, no. 7, 2008, pages 2426 - 2447
LYUBARSKAYA Y ET AL., ANAL BIOCHEM., vol. 348, 2006, pages 24 - 39
EAGLE H, SCIENCE, vol. 130, no. 3373, 1959, pages 432 - 437
DULBECCO RFREEMAN G, VIROLOGY, vol. 8, 1959, pages 396 - 397
MOORE GE ET AL., JAM MED ASSOC., vol. 199, 1967, pages 519
MORGAN JF ET AL., PROC SOC EXP BIOL MED., vol. 73, 1950, pages 1 - 8
SMITH GE ET AL., PROC NATL ACAD SCI USA., vol. 82, 1985, pages 8404
"Mol. Clo.", vol. 3, 2001, COLD SPRING HARBOR LABORATORY
BOSTIAN KA ET AL., PROC NATL ACAD SCI USA., vol. 77, 1980, pages 4504 - 4508
"NCBI", Database accession no. NP_057223.1
WITTLE N ET AL., PROTEIN ENGINEERING, vol. 1, no. 6, 1987, pages 499 - 505
AULINO P ET AL., BCM CANCER, vol. 10, no. 363, 2010, pages 1 - 15
BONETTO A ET AL., J VIS EXP., vol. 117, 30 November 2016 (2016-11-30), pages 1 - 21
See also references of EP 3875114A4
EVANS WJ ET AL., CLIN NUTR., vol. 27, 2008, pages 793 - 799
BARACOS VE ET AL., NAT REV DIS PRIMERS, vol. 4, 2018, pages 1 - 18
WINKLES JA, NAT REV DRUG DISCOV., vol. 7, 2008, pages 411 - 425
CULP PA ET AL., CLIN CANCER RES., vol. 16, 2010, pages 497 - 508
HU G ET AL., TUMOR BIOL., vol. 39, June 2017 (2017-06-01), pages 1 - 9
JOHNSTON AJ ET AL., CELL, vol. 162, 2015, pages 1365 - 1378
LAM ET ET AL., MOL CANCER THER., vol. 17, 2018, pages 215 - 221
CHOI D ET AL., AM J PHARMACOL TOXICOL., vol. 12, 2017, pages 18 - 38
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, UNITED STATES PUBLIC HEALTH SERVICE, NATIONAL INSTITUTE OF HEALTH
LIU H ET AL., J PHAR SCI., vol. 97, no. 7, 2008, pages 2426 - 2447
LYUBARSKAYA Y ET AL., ANAL BIOCHEM., vol. 348, 2006, pages 24 - 39
EAGLE H, SCIENCE, vol. 130, no. 3373, 1959, pages 432 - 437
DULBECCO RFREEMAN G, VIROLOGY, vol. 8, 1959, pages 396 - 397
MOORE GE ET AL., JAM MED ASSOC., vol. 199, 1967, pages 519
MORGAN JF ET AL., PROC SOC EXP BIOL MED., vol. 73, 1950, pages 1 - 8
SMITH GE ET AL., PROC NATL ACAD SCI USA., vol. 82, 1985, pages 8404
"Mol. Clo.", vol. 3, 2001, COLD SPRING HARBOR LABORATORY
BOSTIAN KA ET AL., PROC NATL ACAD SCI USA., vol. 77, 1980, pages 4504 - 4508
"NCBI", Database accession no. NP_057223.1
WITTLE N ET AL., PROTEIN ENGINEERING, vol. 1, no. 6, 1987, pages 499 - 505
AULINO P ET AL., BCM CANCER, vol. 10, no. 363, 2010, pages 1 - 15
BONETTO A ET AL., J VIS EXP., vol. 117, 30 November 2016 (2016-11-30), pages 1 - 21
See also references of EP 3875114A4
Attorney, Agent or Firm:
HAMAI, Kousuke et al. (JP)
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