Title:
ANTI-HUMAN IGG4 MONOCLONAL ANTIBODY AND HUMAN IGG4 ASSAY REAGENT USING SAID ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2019/009346
Kind Code:
A1
Abstract:
Provided are: a monoclonal antibody against human IgG4, for which the epitope is present in the CH3 of human IgG4 given by SEQ ID NO: 4; a hybridoma that produces the monoclonal antibody; a method for detecting IgG4 using the monoclonal antibody; and a kit used in this method.
Inventors:
TERUUCHI YUYA (JP)
MATSUKI YURI (JP)
INAGAKI KAZUMITSU (JP)
SASAKI DAISUKE (JP)
KASHIWAGURA HARUKA (JP)
MATSUKI YURI (JP)
INAGAKI KAZUMITSU (JP)
SASAKI DAISUKE (JP)
KASHIWAGURA HARUKA (JP)
Application Number:
PCT/JP2018/025441
Publication Date:
January 10, 2019
Filing Date:
July 05, 2018
Export Citation:
Assignee:
NITTO BOSEKI CO LTD (JP)
International Classes:
C12N15/13; C07K16/42; C12N5/20; G01N33/53; G01N33/543; G01N33/544; C12P21/08
Domestic Patent References:
| WO2010151792A1 | 2010-12-29 | |||
| WO2017120222A1 | 2017-07-13 | |||
| WO2008012944A1 | 2008-01-31 |
Foreign References:
| JPS61286754A | 1986-12-17 | |||
| JPS61286754A | 1986-12-17 | |||
| JPH04350559A | 1992-12-04 | |||
| JP2001337092A | 2001-12-07 | |||
| JP2001501579A | 2001-02-06 |
Other References:
MATSUKI, YURI ET AL.: "Performance evaluation of IgG4 measurement reagent ''N assay LA IgG4 Nittobo'' in universal automatic analyzer", JAPANESE JOURNAL OF MEDICINE AND PHARMACEUTICAL SCIENCE, vol. 75, no. 7, 27 June 2018 (2018-06-27), pages 849 - 858, XP009518816, ISSN: 0389-3898
VIDARSSON, GESTUR ET AL.: "IgG subclasses and allotypes: from structure to effector functions", FRONTIERS IN IMMUNOLOGY, vol. 5, 20 October 2014 (2014-10-20), pages 1 - 17, XP055166978
JEFFERIS, R. ET AL.: "Evaluation of monoclonal antibodies having specificity for human IgG sub- classes: Results of an IUIS/WHO collaborative study", IMMUNOLOGY LETTERS, vol. 10, no. 3-4, 1985, pages 223 - 252, XP023621177
HARADA, SHIGENORI ET AL.: "Evaluation of Production and Characterization of Monoclonal Antibodies to Human IgG of Four Subclasses", MICROBIOL. IMMUNOL., vol. 33, no. 7, 1989, pages 579 - 592, XP008031358
USAMI, YOKO ET AL.: "Evaluation of basic performance of IgG4 determination reagent measurable by univeral chemistry automatic analyzer", JAPANESE JOURNAL OF CLINICAL LABORATORY AUTOMATION, vol. 39, no. 4, 1 September 2014 (2014-09-01), pages 629, XP009518814
N ENGL J MED, vol. 366, 2012, pages 539 - 551
ARTHRITIS RHEUMATOL., vol. 66, no. 1, January 2014 (2014-01-01), pages 213 - 7
J MOL BIOL., vol. 426, no. 3, 6 February 2014 (2014-02-06), pages 630 - 44
FRONT IMMUNOL., vol. 5, 2014, pages 520
"Consensus statement on the pathology of IgG4-related disease", MODERN PATHOLOGY, vol. 25, 2012, pages 1181 - 1192
"Epitope mapping of human immunoglobulin specific murine monoclonal antibodies with domain switched deleted and point mutated chimeric antibodies", JOURNAL OF IMMUNOLOGICAL METHODS, vol. 158, 1993, pages 107 - 122
KOHLERMILSTEIN, NATURE, vol. 256, 1975, pages 495 - 497
See also references of EP 3650547A4
VIDARSSON, GESTUR ET AL.: "IgG subclasses and allotypes: from structure to effector functions", FRONTIERS IN IMMUNOLOGY, vol. 5, 20 October 2014 (2014-10-20), pages 1 - 17, XP055166978
JEFFERIS, R. ET AL.: "Evaluation of monoclonal antibodies having specificity for human IgG sub- classes: Results of an IUIS/WHO collaborative study", IMMUNOLOGY LETTERS, vol. 10, no. 3-4, 1985, pages 223 - 252, XP023621177
HARADA, SHIGENORI ET AL.: "Evaluation of Production and Characterization of Monoclonal Antibodies to Human IgG of Four Subclasses", MICROBIOL. IMMUNOL., vol. 33, no. 7, 1989, pages 579 - 592, XP008031358
USAMI, YOKO ET AL.: "Evaluation of basic performance of IgG4 determination reagent measurable by univeral chemistry automatic analyzer", JAPANESE JOURNAL OF CLINICAL LABORATORY AUTOMATION, vol. 39, no. 4, 1 September 2014 (2014-09-01), pages 629, XP009518814
N ENGL J MED, vol. 366, 2012, pages 539 - 551
ARTHRITIS RHEUMATOL., vol. 66, no. 1, January 2014 (2014-01-01), pages 213 - 7
J MOL BIOL., vol. 426, no. 3, 6 February 2014 (2014-02-06), pages 630 - 44
FRONT IMMUNOL., vol. 5, 2014, pages 520
"Consensus statement on the pathology of IgG4-related disease", MODERN PATHOLOGY, vol. 25, 2012, pages 1181 - 1192
"Epitope mapping of human immunoglobulin specific murine monoclonal antibodies with domain switched deleted and point mutated chimeric antibodies", JOURNAL OF IMMUNOLOGICAL METHODS, vol. 158, 1993, pages 107 - 122
KOHLERMILSTEIN, NATURE, vol. 256, 1975, pages 495 - 497
See also references of EP 3650547A4
Attorney, Agent or Firm:
ASAMURA PATENT OFFICE, P.C. (JP)
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