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Title:
ANTI-HUMAN IGG4 MONOCLONAL ANTIBODY AND HUMAN IGG4 ASSAY REAGENT USING SAID ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2019/009346
Kind Code:
A1
Abstract:
Provided are: a monoclonal antibody against human IgG4, for which the epitope is present in the CH3 of human IgG4 given by SEQ ID NO: 4; a hybridoma that produces the monoclonal antibody; a method for detecting IgG4 using the monoclonal antibody; and a kit used in this method.

Inventors:
TERUUCHI Yuya (1, Aza Shiojima, Fukuhara, Fukuyamamachi, Koriyama-sh, Fukushima 61, 〒9638061, JP)
MATSUKI Yuri (Koji-Machi O-dori Bldg., 2-4-1, Koji-Machi, Chiyoda-k, Tokyo 83, 〒1020083, JP)
INAGAKI Kazumitsu (1, Aza Shiojima, Fukuhara, Fukuyamamachi, Koriyama-sh, Fukushima 61, 〒9638061, JP)
SASAKI Daisuke (1, Aza Shiojima, Fukuhara, Fukuyamamachi, Koriyama-sh, Fukushima 61, 〒9638061, JP)
KASHIWAGURA Haruka (1, Aza Shiojima, Fukuhara, Fukuyamamachi, Koriyama-sh, Fukushima 61, 〒9638061, JP)
Application Number:
JP2018/025441
Publication Date:
January 10, 2019
Filing Date:
July 05, 2018
Export Citation:
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Assignee:
NITTO BOSEKI CO., LTD. (1 Aza Higashi, Gonome Fukushima-sh, Fukushima 61, 〒9608161, JP)
International Classes:
C12N15/13; C07K16/42; C12N5/20; G01N33/53; G01N33/543; G01N33/544; C12P21/08
Domestic Patent References:
WO2010151792A12010-12-29
WO2017120222A12017-07-13
Foreign References:
JPS61286754A1986-12-17
Other References:
MATSUKI, YURI ET AL.: "Performance evaluation of IgG4 measurement reagent ''N assay LA IgG4 Nittobo'' in universal automatic analyzer", JAPANESE JOURNAL OF MEDICINE AND PHARMACEUTICAL SCIENCE, vol. 75, no. 7, 27 June 2018 (2018-06-27), pages 849 - 858
VIDARSSON, GESTUR ET AL.: "IgG subclasses and allotypes: from structure to effector functions", FRONTIERS IN IMMUNOLOGY, vol. 5, 20 October 2014 (2014-10-20), pages 1 - 17, XP055166978
JEFFERIS, R. ET AL.: "Evaluation of monoclonal antibodies having specificity for human IgG sub- classes: Results of an IUIS/WHO collaborative study", IMMUNOLOGY LETTERS, vol. 10, no. 3-4, 1985, pages 223 - 252, XP023621177
HARADA, SHIGENORI ET AL.: "Evaluation of Production and Characterization of Monoclonal Antibodies to Human IgG of Four Subclasses", MICROBIOL. IMMUNOL., vol. 33, no. 7, 1989, pages 579 - 592, XP008031358
USAMI, YOKO ET AL.: "Evaluation of basic performance of IgG4 determination reagent measurable by univeral chemistry automatic analyzer", JAPANESE JOURNAL OF CLINICAL LABORATORY AUTOMATION, vol. 39, no. 4, 1 September 2014 (2014-09-01), pages 629
Attorney, Agent or Firm:
ASAMURA PATENT OFFICE, P.C. (Tennoz Central Tower, 2-2-24 Higashi-Shinagawa Shinagawa-k, Tokyo 76, 〒1408776, JP)
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