Title:
ANTI-IDIOTYPIC ANTIBODIES AGAINST FACTOR VIII INHIBITOR AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2004014955
Kind Code:
A9
Abstract:
The present invention discloses anti-idiotypic antibodies and fragments thereof against inhibitory Factor VIII antibodies, said inhibitory antibodies having an affinity for the C2 domain of Factor VIII. The anti-idiotypic antibodies of the present invention are able to completely neutralise in vitro and in an in vivo mouse model the inhibitory activity of FVIII inhibitors. The anti idiotypic antibodies of the present invention can be applied for the prevention, treatment or reduction of bleeding disorders of hemophilia patients with inhibitory antibody against the C2 domain of Factor VIII.
Inventors:
GILLES JEAN-GUY G (BE)
SAINT-REMY JEAN-MARIE R (BE)
JACQUEMIN MARC G (BE)
SAINT-REMY JEAN-MARIE R (BE)
JACQUEMIN MARC G (BE)
Application Number:
PCT/EP2003/008365
Publication Date:
March 24, 2005
Filing Date:
July 28, 2003
Export Citation:
Assignee:
D COLLEN RES FOUNDATION VZW (BE)
GILLES JEAN-GUY G (BE)
SAINT-REMY JEAN-MARIE R (BE)
JACQUEMIN MARC G (BE)
GILLES JEAN-GUY G (BE)
SAINT-REMY JEAN-MARIE R (BE)
JACQUEMIN MARC G (BE)
International Classes:
A61K38/08; A61K38/17; C07K14/705; C07K16/42; C12N5/16; (IPC1-7): C07K16/42; C07K14/705; C12N5/16; A61K38/17; A61K38/08
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