Title:
ANTI-INFLAMMATION AGENT FOR INTRAOCULAR APPLICATIONS
Document Type and Number:
WIPO Patent Application WO/2023/090425
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing an anti-inflammation agent for intraocular applications, which can prevent an excessive inflammation in an interocular tissue. The anti-inflammation agent comprises an ERK-activating agent. The problem can also be solved by an anti-inflammation agent for intraocular applications, which comprises at least one component selected from the group consisting of active sulfur molecules respectively represented by general formulae (1) and (2) and derivatives of the active sulfur molecules. R1S(S)nH ・・・(1) (In formula (1), R1 represents a L-cysteine (Cys), homocysteine (HCys) or glutathione (GSH) moiety other than a thiol group; and n represents an integer of 1 or more.) R2S(S)n+1R3 ・・・(2) (In formula (2), R2 and R3 independently represent a L-cysteine (Cys), homocysteine (HCys) or glutathione (GSH) moiety other than a thiol group; and n represents an integer of 1 or more.)
Inventors:
NAKAZAWA TORU (JP)
AKAIKE TAKAAKI (JP)
KUNIKATA HIROSHI (JP)
TAWARAYAMA HIROSHI (JP)
TSUDA SATORU (JP)
AKAIKE TAKAAKI (JP)
KUNIKATA HIROSHI (JP)
TAWARAYAMA HIROSHI (JP)
TSUDA SATORU (JP)
Application Number:
PCT/JP2022/042868
Publication Date:
May 25, 2023
Filing Date:
November 18, 2022
Export Citation:
Assignee:
UNIV TOHOKU (JP)
International Classes:
A61K45/00; A61K31/198; A61K38/06; A61P27/02; A61P29/00
Domestic Patent References:
| WO2017057768A1 | 2017-04-06 | |||
| WO2021235494A1 | 2021-11-25 |
Other References:
TADAHISA NUMAKURA, HISATOSHI SUGIURA, TAKAAKI AKAIKE, MASAKAZU ICHINOSE: "PP245: Study on the production of reactive sulfur species (reactive sulfur species: RSS) in patients with COPD", THE JOURNAL OF THE JAPANESE RESPIRATORY SOCIETY - NIHON-KOKYUKI-GAKKAI-ZASSHI, vol. 57, no. Spec. Iss., 30 November 2016 (2016-11-30) - 23 April 2017 (2017-04-23), pages 191, XP009541467, ISSN: 2186-5876
SAWA, TOMOHIRO: "Reactive sulfur derivatives strongly suppress the inflammatory responses", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 272, no. 11, 14 March 2020 (2020-03-14), JP , pages 1155 - 1157, XP009541529
SAWA TOMOHIRO: "DP14-05 (P-241) Anti-inflammatory activity of reactive sulfur species: mechanisms and therapeutic potentials", NIHON SAIKINGAKU ZASSHI - JAPANESE JOURNAL OF BACTERIOLOGY, vol. 74, no. 1, 1 January 2019 (2019-01-01), pages 90, XP093010195, ISSN: 0021-4930, DOI: 10.3412/jsb.74.44
ZHANG TIANLI, ONO KATSUHIKO, TSUTSUKI HIROYASU, IHARA HIDESHI, ISLAM WALIUL, AKAIKE TAKAAKI, SAWA TOMOHIRO: "Enhanced Cellular Polysulfides Negatively Regulate TLR4 Signaling and Mitigate Lethal Endotoxin Shock", CELL CHEMICAL BIOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 26, no. 5, 1 May 2019 (2019-05-01), AMSTERDAM, NL , pages 686 - 698.e4, XP055875296, ISSN: 2451-9456, DOI: 10.1016/j.chembiol.2019.02.003
CHONG CHEONG-MENG, ZHENG WENHUA: "Artemisinin protects human retinal pigment epithelial cells from hydrogen peroxide-induced oxidative damage through activation of ERK/CREB signaling", REDOX BIOLOGY, ELSEVIER, NL, vol. 9, 1 October 2016 (2016-10-01), NL , pages 50 - 56, XP093068476, ISSN: 2213-2317, DOI: 10.1016/j.redox.2016.06.002
TSAO, Y.P. ; HO, T.C. ; CHEN, S.L. ; CHENG, H.C.: "Pigment epithelium-derived factor inhibits oxidative stress-induced cell death by activation of extracellular signal-regulated kinases in cultured retinal pigment epithelial cells", LIFE SCIENCE, PERGAMON PRESS, OXFORD, GB, vol. 79, no. 6, 4 July 2006 (2006-07-04), GB , pages 545 - 550, XP028050862, ISSN: 0024-3205, DOI: 10.1016/j.lfs.2006.01.041
TAWARAYAMA HIROSHI, SUZUKI NORIYUKI, INOUE-YANAGIMACHI MAKI, HIMORI NORIKO, TSUDA SATORU, SATO KOTA, IDA TOMOAKI, AKAIKE TAKAAKI, : "Glutathione Trisulfide Prevents Lipopolysaccharide-induced Inflammatory Gene Expression in Retinal Pigment Epithelial Cells", OCULAR IMMUNOLOGY AND INFLAMMATION, AEOLUS PRESS, BUREN, NL, vol. ahead-of-print, no. ahead-of-print, 10 December 2020 (2020-12-10), NL , pages 1 - 12, XP009538578, ISSN: 0927-3948, DOI: 10.1080/09273948.2020.1833224
SAWA, TOMOHIRO: "Reactive sulfur derivatives strongly suppress the inflammatory responses", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 272, no. 11, 14 March 2020 (2020-03-14), JP , pages 1155 - 1157, XP009541529
SAWA TOMOHIRO: "DP14-05 (P-241) Anti-inflammatory activity of reactive sulfur species: mechanisms and therapeutic potentials", NIHON SAIKINGAKU ZASSHI - JAPANESE JOURNAL OF BACTERIOLOGY, vol. 74, no. 1, 1 January 2019 (2019-01-01), pages 90, XP093010195, ISSN: 0021-4930, DOI: 10.3412/jsb.74.44
ZHANG TIANLI, ONO KATSUHIKO, TSUTSUKI HIROYASU, IHARA HIDESHI, ISLAM WALIUL, AKAIKE TAKAAKI, SAWA TOMOHIRO: "Enhanced Cellular Polysulfides Negatively Regulate TLR4 Signaling and Mitigate Lethal Endotoxin Shock", CELL CHEMICAL BIOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 26, no. 5, 1 May 2019 (2019-05-01), AMSTERDAM, NL , pages 686 - 698.e4, XP055875296, ISSN: 2451-9456, DOI: 10.1016/j.chembiol.2019.02.003
CHONG CHEONG-MENG, ZHENG WENHUA: "Artemisinin protects human retinal pigment epithelial cells from hydrogen peroxide-induced oxidative damage through activation of ERK/CREB signaling", REDOX BIOLOGY, ELSEVIER, NL, vol. 9, 1 October 2016 (2016-10-01), NL , pages 50 - 56, XP093068476, ISSN: 2213-2317, DOI: 10.1016/j.redox.2016.06.002
TSAO, Y.P. ; HO, T.C. ; CHEN, S.L. ; CHENG, H.C.: "Pigment epithelium-derived factor inhibits oxidative stress-induced cell death by activation of extracellular signal-regulated kinases in cultured retinal pigment epithelial cells", LIFE SCIENCE, PERGAMON PRESS, OXFORD, GB, vol. 79, no. 6, 4 July 2006 (2006-07-04), GB , pages 545 - 550, XP028050862, ISSN: 0024-3205, DOI: 10.1016/j.lfs.2006.01.041
TAWARAYAMA HIROSHI, SUZUKI NORIYUKI, INOUE-YANAGIMACHI MAKI, HIMORI NORIKO, TSUDA SATORU, SATO KOTA, IDA TOMOAKI, AKAIKE TAKAAKI, : "Glutathione Trisulfide Prevents Lipopolysaccharide-induced Inflammatory Gene Expression in Retinal Pigment Epithelial Cells", OCULAR IMMUNOLOGY AND INFLAMMATION, AEOLUS PRESS, BUREN, NL, vol. ahead-of-print, no. ahead-of-print, 10 December 2020 (2020-12-10), NL , pages 1 - 12, XP009538578, ISSN: 0927-3948, DOI: 10.1080/09273948.2020.1833224
Attorney, Agent or Firm:
IP FIRM SHUWA (JP)
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