Title:
ANTI-INFLAMMATORY ANALGESIC COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/087632
Kind Code:
A1
Abstract:
The present invention belongs to the field of medicinal chemistry, and specifically disclosed are an anti-inflammatory analgesic compound and the use thereof. The compound of the present invention is a compound having a structure shown in formula (I) or formula (II), an isomer or a pharmaceutically acceptable salt thereof. The compound of the present application has a significant curative effect on gouty arthritis in rats, and also has a good anti-inflammatory factor effect. Therefore, the compound has potential application prospects in the aspects of anti-inflammatory analgesic drugs, particularly anti-acute gouty arthritis drugs, anti-rheumatoid arthritis drugs, drugs for reducing inflammatory factors, drugs for treating inflammatory storms or coronavirus pneumonia drugs, etc.
Inventors:
SHI DONGFANG (CN)
FU CHANGJIN (CN)
YANG YAN (CN)
LI HAIMING (CN)
FU CHANGJIN (CN)
YANG YAN (CN)
LI HAIMING (CN)
Application Number:
PCT/CN2022/090947
Publication Date:
May 25, 2023
Filing Date:
May 05, 2022
Export Citation:
Assignee:
JIANGSU ATOM BIOSCIENCE AND PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K31/165; C07D307/20; A61K31/17; A61K31/18; A61K31/196; A61K31/255; A61K31/27; A61K31/277; A61K31/341; A61K31/40; A61K31/41; A61K31/421; A61K31/495; A61K31/5375; A61K31/64; A61K31/69; A61P19/02; A61P29/00; A61P31/14; C07C233/32; C07C233/52; C07C237/24; C07C255/19; C07C255/47; C07C271/24; C07C271/34; C07C275/26; C07C305/20; C07C307/02; C07C307/08; C07C311/07; C07C311/46; C07D207/16; C07D207/27; C07D249/08; C07D257/04; C07D263/24; C07D265/32; C07D295/155; C07D295/182; C07F5/02
Foreign References:
| CN114656429A | 2022-06-24 | |||
| CN102741223A | 2012-10-17 |
Other References:
KUREK JOANNA, MYSZKOWSKI KRZYSZTOF, OKULICZ-KOZARYN IRENA, KURANT AGNIESZKA, KAMIŃSKA EWA, SZULC MICHAŁ, RUBIŚ BŁAŻEJ, KACZMAREK M: "Cytotoxic, analgesic and anti-inflammatory activity of colchicine and its C-10 sulfur containing derivatives", SCIENTIFIC REPORTS, vol. 11, no. 1, pages 9034, XP093068014, DOI: 10.1038/s41598-021-88260-1
PARé GUILLAUME; VITRY JULIEN; MARCEAU FRANçOIS; VAILLANCOURT MYRIAM; WINTER PHILIP; BACHELARD HéLèNE; NACCACHE: "The development of a targeted and more potent, anti-Inflammatory derivative of colchicine: Implications for gout", BIOCHEMICAL PHARMACOLOGY, ELSEVIER, US, vol. 180, 26 June 2020 (2020-06-26), US , XP086286176, ISSN: 0006-2952, DOI: 10.1016/j.bcp.2020.114125
GHAWANMEH ABDULLAH A.; AL-BAJALAN HUSSEIN M.; MACKEEN MUKRAM MOHAMED; ALALI FERAS Q.; CHONG KWOK FENG: "Recent developments on (-)-colchicine derivatives: Synthesis and structure-activity relationship", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 185, 18 October 2019 (2019-10-18), AMSTERDAM, NL , XP085935541, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2019.111788
PARé GUILLAUME; VITRY JULIEN; MARCEAU FRANçOIS; VAILLANCOURT MYRIAM; WINTER PHILIP; BACHELARD HéLèNE; NACCACHE: "The development of a targeted and more potent, anti-Inflammatory derivative of colchicine: Implications for gout", BIOCHEMICAL PHARMACOLOGY, ELSEVIER, US, vol. 180, 26 June 2020 (2020-06-26), US , XP086286176, ISSN: 0006-2952, DOI: 10.1016/j.bcp.2020.114125
GHAWANMEH ABDULLAH A.; AL-BAJALAN HUSSEIN M.; MACKEEN MUKRAM MOHAMED; ALALI FERAS Q.; CHONG KWOK FENG: "Recent developments on (-)-colchicine derivatives: Synthesis and structure-activity relationship", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 185, 18 October 2019 (2019-10-18), AMSTERDAM, NL , XP085935541, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2019.111788
Attorney, Agent or Firm:
NANJING SITUO INTELLECTUAL PROPERTY AGENCY (GP) (CN)
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