Title:
ANTI-NLS SCFV AND PEPTIDES AND USES THEREOF IN NUCLEAR IMPORT INHIBITION
Document Type and Number:
WIPO Patent Application WO2003089472
Kind Code:
A3
Abstract:
The present invention relates to a substance that specifically binds a nuclear localization signal (NLS)-containing molecule. Said substance may be a naturally occurring, synthetic or recombinant antibody, or it may be a protein, a peptide or a small molecule. Preferably, said NLS-containing molecule is a HIV-1 protein, more preferably Vpr or Tat. In addition, the present invention relates to a composition or a vaccine comprising the substance of the invention, as well as methods of inhibiting viral infection through the administration thereof.
Inventors:
LOYTER ABRAHAM (IL)
GRAESSMAN ADOLF (DE)
NISSIM AHUVA (IL)
KRICHEVSKY ALEXANDER (IL)
ZAKAI NECHAMA (IL)
GRAESSMAN ADOLF (DE)
NISSIM AHUVA (IL)
KRICHEVSKY ALEXANDER (IL)
ZAKAI NECHAMA (IL)
Application Number:
PCT/IL2003/000328
Publication Date:
May 13, 2004
Filing Date:
April 21, 2003
Export Citation:
Assignee:
YISSUM RES DEV CO (IL)
LOYTER ABRAHAM (IL)
GRAESSMAN ADOLF (DE)
NISSIM AHUVA (IL)
KRICHEVSKY ALEXANDER (IL)
ZAKAI NECHAMA (IL)
LOYTER ABRAHAM (IL)
GRAESSMAN ADOLF (DE)
NISSIM AHUVA (IL)
KRICHEVSKY ALEXANDER (IL)
ZAKAI NECHAMA (IL)
International Classes:
A61P31/18; C07K16/10; A61K38/00; (IPC1-7): C07K16/10; A61K39/42; A61K38/16; C07K14/005; A61P31/18
Domestic Patent References:
| WO1999028338A1 | 1999-06-10 | |||
| WO2000049038A2 | 2000-08-24 |
Other References:
DUBROVSKY LARISA ET AL: "Nuclear localization signal of HIV-1 as a novel target for therapeutic intervention.", MOLECULAR MEDICINE (CAMBRIDGE), vol. 1, no. 2, 1995, pages 217 - 230, XP008021708, ISSN: 1076-1551
KARNI O ET AL: "A peptide derived from the N-terminal region of HIV-1 Vpr promotes nuclear import in permeabilized cells: elucidation of the NLS region of the Vpr", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 429, no. 3, 16 June 1998 (1998-06-16), pages 421 - 425, XP004258047, ISSN: 0014-5793
KARNI O ET AL: "A peptide derived from the N-terminal region of HIV-1 Vpr promotes nuclear import in permeabilized cells: elucidation of the NLS region of the Vpr", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 429, no. 3, 16 June 1998 (1998-06-16), pages 421 - 425, XP004258047, ISSN: 0014-5793
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