Title:
ANTI-PD-1/ANTI-HER2 NATURAL ANTIBODY STRUCTURE-LIKE BISPECIFIC ANTIBODY OF HETERODIMERIC FORM AND PREPARATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/090950
Kind Code:
A1
Abstract:
Provided are an anti-PD-1/anti-HER2 bispecific antibody of a heterodimeric form having the characteristics of a natural IgG and a preparation method therefor. The antibody binds both target molecules simultaneously, and can be used to treat complex diseases.
More Like This:
Inventors:
LIU JIAWANG (CN)
SONG NANMENG (CN)
YANG YAPING (CN)
KIM MAENGSUP (CN)
SONG NANMENG (CN)
YANG YAPING (CN)
KIM MAENGSUP (CN)
Application Number:
PCT/CN2017/111310
Publication Date:
May 24, 2018
Filing Date:
November 16, 2017
Export Citation:
Assignee:
BEIJING HANMI PHARMACEUTICAL CO LTD (CN)
International Classes:
C07K16/30; A61K39/395; A61P35/00; C07K16/28; C07K16/46
Domestic Patent References:
| WO2015095412A1 | 2015-06-25 | |||
| WO2013060867A2 | 2013-05-02 | |||
| WO2009089004A1 | 2009-07-16 | |||
| WO2012058768A1 | 2012-05-10 |
Foreign References:
| CN105828837A | 2016-08-03 | |||
| CN104114579A | 2014-10-22 | |||
| US5731168A | 1998-03-24 |
Other References:
CHOI, H.J. ET AL.: "Engineering of Immunoglobulin Fc Heterodimers Using Yeast Surface-Displayed Combinatorial Fc Library Screening", PLOS ONE, vol. 10, no. 12, 16 December 2015 (2015-12-16), XP055377972, ISSN: 1932-6203
ANTICANCER AGENTS MED CHEM., vol. 15, no. 3, 2015, pages 307 - 13
HEMATOL ONCOL STEM CELL THER., vol. 7, no. 1, March 2014 (2014-03-01), pages 1 - 17
TRENDS MOL MED., vol. 21, no. 1, January 2015 (2015-01-01), pages 24 - 33
IMMUNITY, vol. 39, no. 1, 25 July 2013 (2013-07-25), pages 61 - 73
J CLIN ONCOL., vol. 33, no. 17, 10 June 2015 (2015-06-10), pages 1974 - 82
AUTOIMMUN REV, vol. 12, no. 11, 2013, pages 1091 - 1100
FRONT IMMUNOL, vol. 4, 2013, pages 481
NAT REV CANCER, vol. 12, no. 4, 2012, pages 252 - 264
SALMAN DJ ET AL., SCIENCE, vol. 235, 1985, pages 177 - 182
REVILLION F ET AL., EUR J CANCER, vol. 34, 1998, pages 791 - 808
WRIGHT C ET AL., CANCER RES, vol. 49, 1989, pages 2087 - 2090
CARTER P ET AL., PNAS, vol. 89, no. 10, 1992, pages 4285 - 4289
SLAMON DJ ET AL., N ENGL J MED, vol. 344, 2001, pages 783 - 792
HAAS C ET AL., IMMUNOBIOLOGY, vol. 214, 2009, pages 441 - 453
LOFFLER ET AL., BLOOD, vol. 95, pages 2098 - 2103
JAGER M ET AL., CANCER RES, vol. 72, 2012, pages 24 - 32
See also references of EP 3533804A4
ANTICANCER AGENTS MED CHEM., vol. 15, no. 3, 2015, pages 307 - 13
HEMATOL ONCOL STEM CELL THER., vol. 7, no. 1, March 2014 (2014-03-01), pages 1 - 17
TRENDS MOL MED., vol. 21, no. 1, January 2015 (2015-01-01), pages 24 - 33
IMMUNITY, vol. 39, no. 1, 25 July 2013 (2013-07-25), pages 61 - 73
J CLIN ONCOL., vol. 33, no. 17, 10 June 2015 (2015-06-10), pages 1974 - 82
AUTOIMMUN REV, vol. 12, no. 11, 2013, pages 1091 - 1100
FRONT IMMUNOL, vol. 4, 2013, pages 481
NAT REV CANCER, vol. 12, no. 4, 2012, pages 252 - 264
SALMAN DJ ET AL., SCIENCE, vol. 235, 1985, pages 177 - 182
REVILLION F ET AL., EUR J CANCER, vol. 34, 1998, pages 791 - 808
WRIGHT C ET AL., CANCER RES, vol. 49, 1989, pages 2087 - 2090
CARTER P ET AL., PNAS, vol. 89, no. 10, 1992, pages 4285 - 4289
SLAMON DJ ET AL., N ENGL J MED, vol. 344, 2001, pages 783 - 792
HAAS C ET AL., IMMUNOBIOLOGY, vol. 214, 2009, pages 441 - 453
LOFFLER ET AL., BLOOD, vol. 95, pages 2098 - 2103
JAGER M ET AL., CANCER RES, vol. 72, 2012, pages 24 - 32
See also references of EP 3533804A4
Attorney, Agent or Firm:
BEIJING INTELLEGAL INTELLECTUAL PROPERTY AGENT LTD. (CN)
Download PDF: