ANTI-PD-L1 ANTIBODIES AND USES THEREOF

Title:

ANTI-PD-L1 ANTIBODIES AND USES THEREOF

Document Type and Number:

WIPO Patent Application WO/2019/185029

Kind Code:

A1

Abstract:

Provided are anti-PD-L1 antibodies or fragments thereof. The antibodies or fragments thereof specifically bind to the immunoglobulin C domain of the PD-L1 protein. In various example, the antibodies or fragments thereof include a VH CDR1 of SEQ ID NO: 1, a VH CDR2 of SEQ ID NO: 116, a VH CDR3 of SEQ ID NO: 117, a VL CDR1 of SEQ ID NO: 4, a VL CDR2 of SEQ ID NO: 5, and a VL CDR3 of SEQ ID NO: 6, or variants of each thereof. Methods of using the antibodies or fragments thereof for treating and diagnosing diseases such as cancer and infectious diseases are also provided.

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Inventors:

FANG LEI (CN)
WANG YONGQIANG (CN)
WANG ZHENGYI (CN)
GUO BINGSHI (CN)
ZANG JINGWU (CN)

Application Number:

PCT/CN2019/080458

Publication Date:

October 03, 2019

Filing Date:

March 29, 2019

Export Citation:

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Assignee:

I MAB (KY)

International Classes:

C07K16/28; A61K39/395; A61P35/00; C07K16/46; C12N15/13

Domestic Patent References:

WO2016000619A1	2016-01-07
WO2017118321A1	2017-07-13

Foreign References:

CN105777906A	2016-07-20
CN107488229A	2017-12-19

Other References: