Title:
ANTI-TIM-3 ANTIGEN ANTIBODY OR ANTIBODY DERIVATIVE, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/286854
Kind Code:
A1
Abstract:
[Problem] The present invention addresses the problems of: developing an antibody or an antibody derivative having an enhanced function targeting a Tim-3 antigen, or more specifically, an antibody, etc., having an enhanced immunosuppressive signal removal activity; and a cancer treatment composition including such an antibody, etc. [Solution] The present invention has shown that the problem can be solved upon finding, inter alia, an antibody that includes a heavy/light-chain complementarity-determining region having a specific amino acid sequence, exhibits binding properties with respect to a Tim-3 antigen, and activates T-cells having toxicity against cancer cells.
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Inventors:
NAKAJIMA KANTO (JP)
SHIRAISHI MAMORU (JP)
ARAMAKI TAKAHIKO (JP)
MATSUMURA HARUKA (JP)
MATSUMOTO NORIKO (JP)
SHIRAISHI MAMORU (JP)
ARAMAKI TAKAHIKO (JP)
MATSUMURA HARUKA (JP)
MATSUMOTO NORIKO (JP)
Application Number:
PCT/JP2022/027809
Publication Date:
January 19, 2023
Filing Date:
July 15, 2022
Export Citation:
Assignee:
BRIGHTPATH BIOTHERAPEUTICS CO LTD (JP)
International Classes:
C07K16/28; A61K39/395; A61K47/55; A61K47/68; A61P35/00; A61P37/04; C07K16/46; C12M1/34; C12N15/13; C12Q1/02; G01N33/50
Domestic Patent References:
| WO2017055393A1 | 2017-04-06 |
Foreign References:
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Other References:
GRABMEIER-PFISTERSHAMMER KATHARINA; STECHER CARMEN; ZETTL MARKUS; ROSSKOPF SANDRA; RIEGER ARMIN; ZLABINGER GERHARD J.; STEINBERGER: "Antibodies targeting BTLA or TIM-3 enhance HIV-1 specific T cell responses in combination with PD-1 blockade", CLINICAL IMMUNOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 183, 1 January 1900 (1900-01-01), AMSTERDAM, NL , pages 167 - 173, XP085257011, ISSN: 1521-6616, DOI: 10.1016/j.clim.2017.09.002
HAYASHI EIICHI, EGUCHI JUNICHI, SAKAKI MASASHI, DOI HIROYOSHI, OMORI RISA, KAJIWARA ATSUSHI, YOSHIDA HITOSHI: "Anti-TIM-3 Antibody Prevents Lymphocyte Apoptosis and Enhances Dendritic Cell Cancer Therapy", THE SHOWA UNIVERSITY JOURNAL OF MEDICAL SCIENCES, SHOWA UNIVERSITY, TOKYO,, JP, vol. 27, no. 1, 1 January 2015 (2015-01-01), JP , pages 1 - 9, XP093023872, ISSN: 0915-6380, DOI: 10.15369/sujms.27.1
AKIBA HIROKI, TSUMOTO KOUHEI: "Development and activities, including immunocomplex formation, of biparatopic antibodies and alternative scaffold proteins", TRANSLATIONAL AND REGULATORY SCIENCES, vol. 2, no. 1, 1 January 2020 (2020-01-01), pages 1 - 6, XP055926078, DOI: 10.33611/trs.2_1
MISHIMA YUJI, NAKAJIMA KANTO, SHIRAISHI MAMORU, MATSUMURA HARUKA, ARAMAKI TAKAHIKO, MATSUMOTO NORIKO, NAKAMURA NORIHIRO: "Novel biparatopic TIM3 antibody effectively blocks multiple inherent ligands and activates anti-tumor immunity ", SITC 36TH ANNIVERSARY ANNUAL MEETING (SITC2021) ABSTRACTS, NO.235. JOURNAL OF IMMUNOTHERAPY OF CANCER, 1 November 2021 (2021-11-01), XP093023870, Retrieved from the Internet [retrieved on 20230214]
ISABEL SADA-OVALLE ET AL., J. IMMUNOL., vol. 189, no. 12, 2012, pages 5896 - 902
CHEN ZHU ET AL., NAT. IMMUNOL., vol. 6, no. 12, 2005, pages 1245 - 52
YOSHIKANE KIKUSHIGE ET AL., CELL STEM CELL, vol. 17, 2015, pages 341 - 352
KOHLERMILSTEIN ET AL., NATURE, vol. 256, 1975, pages 495 - 97
HONGO ET AL., HYBRIDOMA, vol. 14, no. 3, 1995, pages 253 - 260
HARLOW ET AL.: "Antibodies: A Laboratory Manual", vol. 2, 1988, COLD SPRING HARBOR LABORATORY PRESS
HAMMERLING ET AL.: "Monoclonal Antibodies and T-Cell Hybridomas", 1981, ELSEVIER, pages: 563 - 681
CLIN. MICROBIOL. REV., vol. 7, 1994, pages 277 - 289
HAYASHI EIICHI, EGUCHI JUNICHI, SAKAKI MASASHI, DOI HIROYOSHI, OMORI RISA, KAJIWARA ATSUSHI, YOSHIDA HITOSHI: "Anti-TIM-3 Antibody Prevents Lymphocyte Apoptosis and Enhances Dendritic Cell Cancer Therapy", THE SHOWA UNIVERSITY JOURNAL OF MEDICAL SCIENCES, SHOWA UNIVERSITY, TOKYO,, JP, vol. 27, no. 1, 1 January 2015 (2015-01-01), JP , pages 1 - 9, XP093023872, ISSN: 0915-6380, DOI: 10.15369/sujms.27.1
AKIBA HIROKI, TSUMOTO KOUHEI: "Development and activities, including immunocomplex formation, of biparatopic antibodies and alternative scaffold proteins", TRANSLATIONAL AND REGULATORY SCIENCES, vol. 2, no. 1, 1 January 2020 (2020-01-01), pages 1 - 6, XP055926078, DOI: 10.33611/trs.2_1
MISHIMA YUJI, NAKAJIMA KANTO, SHIRAISHI MAMORU, MATSUMURA HARUKA, ARAMAKI TAKAHIKO, MATSUMOTO NORIKO, NAKAMURA NORIHIRO: "Novel biparatopic TIM3 antibody effectively blocks multiple inherent ligands and activates anti-tumor immunity ", SITC 36TH ANNIVERSARY ANNUAL MEETING (SITC2021) ABSTRACTS, NO.235. JOURNAL OF IMMUNOTHERAPY OF CANCER, 1 November 2021 (2021-11-01), XP093023870, Retrieved from the Internet
ISABEL SADA-OVALLE ET AL., J. IMMUNOL., vol. 189, no. 12, 2012, pages 5896 - 902
CHEN ZHU ET AL., NAT. IMMUNOL., vol. 6, no. 12, 2005, pages 1245 - 52
YOSHIKANE KIKUSHIGE ET AL., CELL STEM CELL, vol. 17, 2015, pages 341 - 352
KOHLERMILSTEIN ET AL., NATURE, vol. 256, 1975, pages 495 - 97
HONGO ET AL., HYBRIDOMA, vol. 14, no. 3, 1995, pages 253 - 260
HARLOW ET AL.: "Antibodies: A Laboratory Manual", vol. 2, 1988, COLD SPRING HARBOR LABORATORY PRESS
HAMMERLING ET AL.: "Monoclonal Antibodies and T-Cell Hybridomas", 1981, ELSEVIER, pages: 563 - 681
CLIN. MICROBIOL. REV., vol. 7, 1994, pages 277 - 289
Attorney, Agent or Firm:
UCHIYAMA Tsutomu et al. (JP)
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