Title:
ANTIBODIES TO HUMAN IL-1 beta
Document Type and Number:
WIPO Patent Application WO2002016436
Kind Code:
A3
Abstract:
An IL-1 beta binding molecule, in particular an antibody to human IL-1 beta , especially a human antibody to human IL-1 beta is provided, wherein the CDRs of the heavy and light chains having amino acid sequences as defined, for use in the treatment of an IL-1 mediated disease or disorder, e.g. osteoarthritis, osteoporosis and other inflammatory arthritides.
Inventors:
GRAM HERMANN (DE)
DI PADOVA FRANCO E (CH)
DI PADOVA FRANCO E (CH)
Application Number:
PCT/EP2001/009588
Publication Date:
June 20, 2002
Filing Date:
August 20, 2001
Export Citation:
Assignee:
NOVARTIS AG (CH)
NOVARTIS ERFIND VERWALT GMBH (AT)
GRAM HERMANN (DE)
DI PADOVA FRANCO E (CH)
NOVARTIS ERFIND VERWALT GMBH (AT)
GRAM HERMANN (DE)
DI PADOVA FRANCO E (CH)
International Classes:
C12N15/09; A61K39/395; A61P1/04; A61P3/10; A61P11/00; A61P13/12; A61P19/02; A61P19/04; A61P25/00; A61P29/00; A61P31/04; A61P37/02; A61P37/06; A61P37/08; C07K16/24; C07K19/00; C12P21/02; (IPC1-7): C07K16/00
Domestic Patent References:
| WO1995001997A1 | 1995-01-19 |
Foreign References:
| US4935343A | 1990-06-19 | |||
| US0534858A | 1895-02-26 | |||
| EP0267611A2 | 1988-05-18 |
Other References:
JACKSON J R ET AL: "IN VITRO ANTIBODY MUTARATION IMPROVEMENT OF A HIGH AFFINITY, NEUTRALIZING ANTIBODY AGAINST IL-1BETA", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 154, no. 7, 1 April 1995 (1995-04-01), pages 3310 - 3319, XP000941315, ISSN: 0022-1767
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