Title:
ANTIBODY AGAINST THE ENDOTHELIN RECEPTOR SUBTYPE A, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/155151
Kind Code:
A3
Abstract:
The present invention relates to antibodies against the endothelin receptor subtype A, in particular monoclonal antibodies, fragments or derivatives thereof. The present invention also relates to the therapeutic or diagnostic use of this antibody or as a research tool in the field of cancers, in particular glioblastoma.
Inventors:
BOQUET DIDIER (FR)
HERBET AMAURY (FR)
DUCANCEL FRÉDÉRIC (FR)
COSTA NARCISO (FR)
COURAUD JEAN-YVES (FR)
HUGNOT JEAN-PHILIPPE (FR)
HERBET AMAURY (FR)
DUCANCEL FRÉDÉRIC (FR)
COSTA NARCISO (FR)
COURAUD JEAN-YVES (FR)
HUGNOT JEAN-PHILIPPE (FR)
Application Number:
PCT/FR2019/050245
Publication Date:
December 12, 2019
Filing Date:
February 04, 2019
Export Citation:
Assignee:
COMMISSARIAT ENERGIE ATOMIQUE (FR)
International Classes:
C07K16/28; A61P35/00; G01N33/53
Domestic Patent References:
| WO2007095353A2 | 2007-08-23 |
Foreign References:
| CA2971491A1 | 2017-06-08 | |||
| CN103728454A | 2014-04-16 |
Other References:
IRANI SOUSSAN ET AL: "A review of the profile of endothelin axis in cancer and its management", CRITICAL REVIEWS IN ONCOLOGY/HEMATOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 89, no. 2, 4 September 2013 (2013-09-04), pages 314 - 321, XP028817538, ISSN: 1040-8428, DOI: 10.1016/J.CRITREVONC.2013.08.011
RUDIKOFF S ET AL: "Single amino acid substitution altering antigen-binding specificity", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES (PNAS), US, vol. 79, 1 March 1982 (1982-03-01), pages 1979 - 1983, XP007901436, ISSN: 0027-8424, DOI: 10.1073/PNAS.79.6.1979
A. HERBET ET AL: "Antibodies Targeting Human Endothelin-1 Receptors Reveal Different Conformational States in Cancer Cells", PHYSIOLOGICAL RESEARCH., 6 May 2018 (2018-05-06), CZ, pages S257 - S264, XP055635431, ISSN: 0862-8408, DOI: 10.33549/physiolres.933848
RUDIKOFF S ET AL: "Single amino acid substitution altering antigen-binding specificity", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES (PNAS), US, vol. 79, 1 March 1982 (1982-03-01), pages 1979 - 1983, XP007901436, ISSN: 0027-8424, DOI: 10.1073/PNAS.79.6.1979
A. HERBET ET AL: "Antibodies Targeting Human Endothelin-1 Receptors Reveal Different Conformational States in Cancer Cells", PHYSIOLOGICAL RESEARCH., 6 May 2018 (2018-05-06), CZ, pages S257 - S264, XP055635431, ISSN: 0862-8408, DOI: 10.33549/physiolres.933848
Attorney, Agent or Firm:
AUDIER, Philippe (FR)
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