Title:
ANTIBODY OR ANTIGEN BINDING FRAGMENT THEREOF FOR SPECIFICALLY RECOGNIZING B CELL MALIGNANCY, CHIMERIC ANTIGEN RECEPTOR COMPRISING SAME, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/112347
Kind Code:
A2
Abstract:
The present invention relates to a new antibody or an antigen binding fragment thereof for use in the treatment of cancer by targeting a B cell malignancy, a chimeric antigen receptor comprising the same, and a use of the same. The antibody of the present invention is an antibody for specifically binding to CD19 that is highly expressed in cancer cells (particularly, blood cancer), has very low homology to a CDR sequence thereof compared to a CDR sequence of a conventional CD19 target antibody so that the sequence thereof is unique, and specifically binds to an epitope that is different from a FMC63 antibody fragment binding to CD19 of the conventional art. A cell expressing the chimeric antigen receptor comprising an anti-CD19 antibody or the antigen binding fragment of the present invention induces immune cell activity in response to a positive cell line expressing CD19, and thus may be utilized as a CAR-immune cell therapeutic agent.
Inventors:
LEE JONG SEO (KR)
KIM KYU TAE (KR)
KO BONG KOOK (KR)
KIM KI HYUN (KR)
KIM KYU TAE (KR)
KO BONG KOOK (KR)
KIM KI HYUN (KR)
Application Number:
PCT/KR2018/015445
Publication Date:
June 13, 2019
Filing Date:
December 06, 2018
Export Citation:
Assignee:
ABCLON INC (KR)
Foreign References:
| KR20170016969A | 2017-02-14 | |||
| US4554101A | 1985-11-19 | |||
| US9074002B2 | 2015-07-07 |
Other References:
MAUDE ET AL., N ENG J MED, vol. 371, 2014, pages 1507
TOPP ET AL., J CLIN ONCOL, vol. 32, 2014, pages 4134
NICHOLSON ET AL., MOLECULAR IMMUNOLOGY, vol. 34, no. 16-17, 1997, pages 1157 - 1165
KOCHENDERFER ET AL., NATURE REVIEW CLINICAL ONCOL., vol. 10, no. 5, 2013, pages 267 - 276
PORTER ET AL., NEW ENG. J. MED., vol. 365, no. 8, 2011, pages 725 - 733
KALOS ET AL., SCIENCE TRANSLATIONAL MEDICINE, vol. 3, no. 95, 2011, pages 95ra73
KOCHENDERFER ET AL., BLOOD, vol. 116, no. 20, 2010, pages 4099 - 4102
KOCHENDERFER ET AL., BLOOD, vol. 119, no. 12, 2012, pages 2709 - 2720
KINDT ET AL.: "Kuby Immunology", 2007, W.H. FREEMAN AND CO., pages: 91
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1987, U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES
H. NEURATHR.L.HILL: "The Proteins", 1979, ACADEMIC PRESS
SCHEIT: "Nucleotide Analogs", 1980, JOHN WILEY
UHLMANPEYMAN, CHEMICAL REVIEWS, vol. 90, 1990, pages 543 - 584
SMITHWATERMAN: "Adv. Appl. Math.", vol. 2, 1981, pages: 482
NEEDLEMANWUNSCH: "J. Mol. Bio.", vol. 48, 1970, pages: 443
HIGGINSSHARP, GENE, vol. 73, 1988, pages 237 - 44
HIGGINSSHARP, CABIOS, vol. 5, 1989, pages 151 - 3
CORPET ET AL., NUC. ACIDS RES., vol. 16, 1988, pages 10881 - 90
HUANG ET AL., COMP. APPL. BIOSCI., vol. 8, 1992, pages 155 - 65
PEARSON ET AL., METH. MOL. BIOL., vol. 24, 1994, pages 307 - 31
ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 10
SAMBROOK ET AL.: "Molecular Cloning, A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
"Remington's Pharmaceutical Sciences", 1995
SOMMERMEYER D ET AL., LEUKEMIA, vol. 31, no. 10, 2017, pages 2191
BROCHET, X. ET AL., NUCL ACIDS RES., vol. 36, 2008, pages 503 - 508
See also references of EP 3722313A4
TOPP ET AL., J CLIN ONCOL, vol. 32, 2014, pages 4134
NICHOLSON ET AL., MOLECULAR IMMUNOLOGY, vol. 34, no. 16-17, 1997, pages 1157 - 1165
KOCHENDERFER ET AL., NATURE REVIEW CLINICAL ONCOL., vol. 10, no. 5, 2013, pages 267 - 276
PORTER ET AL., NEW ENG. J. MED., vol. 365, no. 8, 2011, pages 725 - 733
KALOS ET AL., SCIENCE TRANSLATIONAL MEDICINE, vol. 3, no. 95, 2011, pages 95ra73
KOCHENDERFER ET AL., BLOOD, vol. 116, no. 20, 2010, pages 4099 - 4102
KOCHENDERFER ET AL., BLOOD, vol. 119, no. 12, 2012, pages 2709 - 2720
KINDT ET AL.: "Kuby Immunology", 2007, W.H. FREEMAN AND CO., pages: 91
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1987, U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES
H. NEURATHR.L.HILL: "The Proteins", 1979, ACADEMIC PRESS
SCHEIT: "Nucleotide Analogs", 1980, JOHN WILEY
UHLMANPEYMAN, CHEMICAL REVIEWS, vol. 90, 1990, pages 543 - 584
SMITHWATERMAN: "Adv. Appl. Math.", vol. 2, 1981, pages: 482
NEEDLEMANWUNSCH: "J. Mol. Bio.", vol. 48, 1970, pages: 443
HIGGINSSHARP, GENE, vol. 73, 1988, pages 237 - 44
HIGGINSSHARP, CABIOS, vol. 5, 1989, pages 151 - 3
CORPET ET AL., NUC. ACIDS RES., vol. 16, 1988, pages 10881 - 90
HUANG ET AL., COMP. APPL. BIOSCI., vol. 8, 1992, pages 155 - 65
PEARSON ET AL., METH. MOL. BIOL., vol. 24, 1994, pages 307 - 31
ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 10
SAMBROOK ET AL.: "Molecular Cloning, A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
"Remington's Pharmaceutical Sciences", 1995
SOMMERMEYER D ET AL., LEUKEMIA, vol. 31, no. 10, 2017, pages 2191
BROCHET, X. ET AL., NUCL ACIDS RES., vol. 36, 2008, pages 503 - 508
See also references of EP 3722313A4
Attorney, Agent or Firm:
YOON, Dae Woong (KR)
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