ANTIBODY FOR ASSAY OF ADAMTS13 ACTIVITY AND METHOD OF ACTIVITY ASSAY

WIPO Patent Application WO/2006/085441

A1

It is intended to provide an antibody, especially monoclonal antibody, useful for the determination of ADAMTS13 activity, and provide a method of determining the activity of ADAMTS13. Further, it is intended to provide a monoclonal antibody that exhibits specific reactivity to any antigen determinant site occurring when ADAMTS13 is caused to act on a partial peptide of VWF able to become a substrate or VWF as a substrate but has no specific reactivity to complete VWF molecules, and to provide a usage of the antibody. These have been achieved by success in obtaining of a monoclonal antibody (anti-N-10 monoclonal antibody) having specific reactivity to cleavage site at which a partial peptide of VWF is specifically cut by ADAMTS13 and by finding of a method of determining the ADAMTS13 activity by the use of this monoclonal antibody.

KATO SEIJI (JP)
HIURA HISAHIDE (JP)
FUJIMURA YOSHIHIRO (JP)
MATSUMOTO MASANORI (JP)

PCT/JP2006/301231

August 17, 2006

January 26, 2006

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JAPAN CLINICAL LAB INC (JP)
KATO SEIJI (JP)
HIURA HISAHIDE (JP)
FUJIMURA YOSHIHIRO (JP)
MATSUMOTO MASANORI (JP)

C07K16/18; C12N15/07; G01N33/53

WO2004035778A1	2004-04-29
WO2005008241A1	2005-01-27

OOUMI S.: "Cell technology Separate Volume Jikken Protocol Series New Edition Anti-peptide Kotai Jikken Protocol - Idenshi Sanbutsu no Dotei kara Tanpakushitsu Kino Kaiseki made -", SHUJUNSHA CO., LTD., 2004, pages 130 - 143, XP003000547
See also references of EP 1852442A4

Shoji, Takashi (2-10 Iwamotocho 3-chom, Chiyoda-ku Tokyo, JP)

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