Title:
ANTIBODY-CYTOKINE FUSION PROTEINS AND APPLICATIONS THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/104134
Kind Code:
A1
Abstract:
Provided are antibody-cytokine fusion proteins comprising an anti-PD-L1 antibody and an Interleukin 21, and methods for preparing the same, as well as applications of the fusion proteins for therapeutic purpose.
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Inventors:
QIN GANG (CN)
SONG PAUL H (CN)
YANG DONG (CN)
LV CAO (CN)
SONG PAUL H (CN)
YANG DONG (CN)
LV CAO (CN)
Application Number:
PCT/CN2022/137449
Publication Date:
June 15, 2023
Filing Date:
December 08, 2022
Export Citation:
Assignee:
GENEQUANTUM HEALTHCARE SUZHOU CO LTD (CN)
International Classes:
C07K19/00; A61K39/395; A61P35/00; C07K14/54; C07K16/30; C12N15/62
Domestic Patent References:
| WO2015165413A1 | 2015-11-05 | |||
| WO2021092719A1 | 2021-05-20 | |||
| WO2020169062A1 | 2020-08-27 |
Foreign References:
| CN110894241A | 2020-03-20 | |||
| CN112638942A | 2021-04-09 |
Other References:
SHEN SHANLING, SCKISEL GAIL, SAHOO ANUPAMA, LALANI ALMIN, OTTER DOUG DEN, PEARSON JOSH, DEVOSS JASON, CHENG JAY, CASEY STEPHANIE C: "Engineered IL-21 Cytokine Muteins Fused to Anti-PD-1 Antibodies Can Improve CD8+ T Cell Function and Anti-tumor Immunity", FRONTIERS IN IMMUNOLOGY, vol. 11, 8 May 2020 (2020-05-08), XP055854614, DOI: 10.3389/fimmu.2020.00832
LI YING, CONG YANNI, JIA MINGMING, HE QIANQIAN, ZHONG HAIQING, ZHAO YUN, LI HANG, YAN MEINING, YOU JIA, LIU JIA, CHEN LIEPING, HAN: "Targeting IL-21 to tumor-reactive T cells enhances memory T cell responses and anti-PD-1 antibody therapy", NATURE COMMUNICATIONS, vol. 12, no. 1, XP093054527, DOI: 10.1038/s41467-021-21241-0
CROCE MICHELA, RIGO VALENTINA, FERRINI SILVANO: "IL-21: A Pleiotropic Cytokine with Potential Applications in Oncology", JOURNAL OF IMMUNOLOGY RESEARCH, HINDAWI PUBLISHING CORPORATION, US, vol. 2015, 1 January 2015 (2015-01-01), US , pages 1 - 15, XP093072551, ISSN: 2314-8861, DOI: 10.1155/2015/696578
PAN XIU-CHENG, LI LI, MAO JUAN-JUAN, YAO WEI, ZHENG JUN-NIAN, LIU MEI, FU JUAN-JUAN: "Synergistic effects of soluble PD-1 and IL-21 on antitumor immunity against H22 murine hepatocellular carcinoma", ONCOLOGY LETTERS, SPANDIDOS PUBLICATIONS, GR, vol. 5, no. 1, 1 January 2013 (2013-01-01), GR , pages 90 - 96, XP093072555, ISSN: 1792-1074, DOI: 10.3892/ol.2012.966
DAVID A. LEVARY, RANGANATH PARTHASARATHY, ERIC T. BODER, MARGARET E. ACKERMAN: "Protein-Protein Fusion Catalyzed by Sortase A", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, US, vol. 6, no. 4, 1 April 2011 (2011-04-01), US , pages e18342.1 - e18342.6, XP002686608, ISSN: 1932-6203, DOI: 10.1371/JOURNAL.PONE.0018342
LI YING, CONG YANNI, JIA MINGMING, HE QIANQIAN, ZHONG HAIQING, ZHAO YUN, LI HANG, YAN MEINING, YOU JIA, LIU JIA, CHEN LIEPING, HAN: "Targeting IL-21 to tumor-reactive T cells enhances memory T cell responses and anti-PD-1 antibody therapy", NATURE COMMUNICATIONS, vol. 12, no. 1, XP093054527, DOI: 10.1038/s41467-021-21241-0
CROCE MICHELA, RIGO VALENTINA, FERRINI SILVANO: "IL-21: A Pleiotropic Cytokine with Potential Applications in Oncology", JOURNAL OF IMMUNOLOGY RESEARCH, HINDAWI PUBLISHING CORPORATION, US, vol. 2015, 1 January 2015 (2015-01-01), US , pages 1 - 15, XP093072551, ISSN: 2314-8861, DOI: 10.1155/2015/696578
PAN XIU-CHENG, LI LI, MAO JUAN-JUAN, YAO WEI, ZHENG JUN-NIAN, LIU MEI, FU JUAN-JUAN: "Synergistic effects of soluble PD-1 and IL-21 on antitumor immunity against H22 murine hepatocellular carcinoma", ONCOLOGY LETTERS, SPANDIDOS PUBLICATIONS, GR, vol. 5, no. 1, 1 January 2013 (2013-01-01), GR , pages 90 - 96, XP093072555, ISSN: 1792-1074, DOI: 10.3892/ol.2012.966
DAVID A. LEVARY, RANGANATH PARTHASARATHY, ERIC T. BODER, MARGARET E. ACKERMAN: "Protein-Protein Fusion Catalyzed by Sortase A", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, US, vol. 6, no. 4, 1 April 2011 (2011-04-01), US , pages e18342.1 - e18342.6, XP002686608, ISSN: 1932-6203, DOI: 10.1371/JOURNAL.PONE.0018342
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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