Title:
ANTIBODY INHIBITING BINDING BETWEEN VEGF AND NRP1
Document Type and Number:
WIPO Patent Application WO/2017/119434
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide an anti-vascular endothelial growth factor (VEGF) antibody that inhibits binding between VEGF and neuropilin-1 (NRP1). Provided is an anti-VEGF antibody that inhibits binding between VEGF and NRP1.
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Inventors:
MURAKAMI YASUFUMI (JP)
SATOFUKA HIROYUKI (JP)
MUKOUBATA SHIGEKI (JP)
AKIYAMA HIROTADA (JP)
KUROSE TATSUJI (JP)
AKAO SAE (JP)
SATOFUKA HIROYUKI (JP)
MUKOUBATA SHIGEKI (JP)
AKIYAMA HIROTADA (JP)
KUROSE TATSUJI (JP)
AKAO SAE (JP)
Application Number:
PCT/JP2017/000100
Publication Date:
July 13, 2017
Filing Date:
January 05, 2017
Export Citation:
Assignee:
ORDER-MADE MEDICAL RES INC (JP)
SANTEN PHARMACEUTICAL CO LTD (JP)
SANTEN PHARMACEUTICAL CO LTD (JP)
International Classes:
C07K16/22; A61K39/395; A61P9/00; A61P27/06; A61P35/00; A61P35/02; A61P37/02; A61P37/06; C12N5/12; C12P21/08; C12N15/02; C12N15/09
Foreign References:
| JP2011256183A | 2011-12-22 | |||
| JP2002543093A | 2002-12-17 | |||
| JP2011500086A | 2011-01-06 |
Other References:
PARKER, MATTHEW W ET AL.: "Structural Basis for Selective Vascular Endothelial Growth Factor-A (VEGF-A)Binding to Neuropilin-1", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 287, no. 14, 2012, pages 11082 - 11089, XP055397506
TOSHIHIKO DOI ET AL.: "VEGF/VEGFR o Kaisuru Bunshi Hyoteki Sogaizai no Rinsho Oyo (Kotai Iyaku o Chushin ni", THE JOURNAL OF THE JAPAN SOCIETY FOR CANCER THERAPY, vol. 42, no. 2, 20 September 2007 (2007-09-20), pages 249, XP009512026, ISSN: 0021-4671
CHENTOUF KHADIDJA-TEHAMI ET AL.: "Production of polyclonal anti VEGF antibodies and establishment of sELISA system for detection serum VEGF level in tumor patients", JOURNAL OF CHEMICAL AND PHARMACEUTICAL RESEARCH, vol. 7, no. 6, 2015, pages 672 - 679, XP055537055
KEYT, BRUCE A ET AL.: "Identification of Vascular Endothelial Growth Factor Determinants for Binding KDR and FLT-1 Receptors", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 10, 1996, pages 5638 - 5646, XP055537060
See also references of EP 3401330A4
TOSHIHIKO DOI ET AL.: "VEGF/VEGFR o Kaisuru Bunshi Hyoteki Sogaizai no Rinsho Oyo (Kotai Iyaku o Chushin ni", THE JOURNAL OF THE JAPAN SOCIETY FOR CANCER THERAPY, vol. 42, no. 2, 20 September 2007 (2007-09-20), pages 249, XP009512026, ISSN: 0021-4671
CHENTOUF KHADIDJA-TEHAMI ET AL.: "Production of polyclonal anti VEGF antibodies and establishment of sELISA system for detection serum VEGF level in tumor patients", JOURNAL OF CHEMICAL AND PHARMACEUTICAL RESEARCH, vol. 7, no. 6, 2015, pages 672 - 679, XP055537055
KEYT, BRUCE A ET AL.: "Identification of Vascular Endothelial Growth Factor Determinants for Binding KDR and FLT-1 Receptors", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 10, 1996, pages 5638 - 5646, XP055537060
See also references of EP 3401330A4
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
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