Title:
ANTIBODY-POLYETHYLENE GLYCOL-PHOTOSENSITIZER CONJUGATE FOR ANTICANCER IMMUNOTHERAPY OF CANCER CELLS
Document Type and Number:
WIPO Patent Application WO/2022/149934
Kind Code:
A1
Abstract:
The present invention relates to an antibody-polyethylene glycol-photosensitizer conjugate for anticancer immunotherapy of cancer cells in which a specific receptor is overexpressed. The conjugate improves the cancer cell targeting ability of antibodies, has excellent singlet oxygen generation efficacy, promotes the maturation of dendritic cells and phagocytosis of cancer cells, promotes the infiltration of immune cells into tumor tissues to exhibit remarkably excellent anticancer effects and exhibits photodynamic therapy effects by means of laser irradiation after in vivo administration.
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Inventors:
NA KUN (KR)
KIM DA HYE (KR)
AHN MIN JI (KR)
KIM DA HYE (KR)
AHN MIN JI (KR)
Application Number:
PCT/KR2022/000394
Publication Date:
July 14, 2022
Filing Date:
January 10, 2022
Export Citation:
Assignee:
CATHOLIC UNIV KOREA IND ACADEMIC COOPERATION FOUNDATION (KR)
ENBIAR INC (KR)
ENBIAR INC (KR)
International Classes:
A61K41/00; A61K39/00; A61K47/60; A61P35/00; C07K16/28; C07K19/00
Domestic Patent References:
| WO2020037303A1 | 2020-02-20 |
Foreign References:
| KR20190085532A | 2019-07-18 | |||
| KR20160038829A | 2016-04-07 | |||
| US20200215206A1 | 2020-07-09 | |||
| US20190125769A1 | 2019-05-02 | |||
| CN108779124A | 2018-11-09 |
Other References:
BRYDEN FRANCESCA, MARUANI ANTOINE, SAVOIE HUGUETTE, CHUDASAMA VIJAY, SMITH MARK E. B., CADDICK STEPHEN, BOYLE ROSS W.: "Regioselective and Stoichiometrically Controlled Conjugation of Photodynamic Sensitizers to a HER2 Targeting Antibody Fragment", BIOCONJUGATE CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 25, no. 3, 19 March 2014 (2014-03-19), US , pages 611 - 617, XP055949431, ISSN: 1043-1802, DOI: 10.1021/bc5000324
Attorney, Agent or Firm:
DANA PATENT LAW FIRM (KR)
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