Title:
ANTIBODY PRODUCTION CONTROLLER
Document Type and Number:
WIPO Patent Application WO/2017/057307
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a drug, a nutritional composition, a food, a drink and a feed, each being capable of promoting the production of IgA antibody and suppressing the production of IgG antibody, which is an autoantibody, so as to achieve both an effect of preventing an infectious disease and an effect of preventing an autoimmune disease. The present inventors conducted intensive studies to search for a factor promoting the production of IgA antibody and suppressing the production of IgG antibody, which is an autoantibody, in vivo and consequently found a lactic acid bacterium of Lactobacillus helveticus, thereby completing the present invention. The constitution of the present invention is as follows. (1) An antibody production controller promoting the production of IgA antibody and suppressing the production of IgG antibody which is an autoantibody, said antibody production controller comprising, as an active ingredient, a lactic acid bacterium belonging to Lactobacillus helveticus or a culture thereof.
Inventors:
HOSOYA TOMOHIRO (JP)
OGAWA AKIHIRO (JP)
TAKAGI KURUMI (JP)
SAKAI FUMIHIKO (JP)
OGAWA AKIHIRO (JP)
TAKAGI KURUMI (JP)
SAKAI FUMIHIKO (JP)
Application Number:
PCT/JP2016/078337
Publication Date:
April 06, 2017
Filing Date:
September 27, 2016
Export Citation:
Assignee:
MEGMILK SNOW BRAND CO LTD (JP)
International Classes:
A61K35/747; A23K10/16; A23L33/135; A61K35/74; A61P37/02
Other References:
TOMOHIRO HOSOYA ET AL.: "Lactobacillus helveticus SBT2171 inhibits lymphocyte proliferation by regulation of the JNK signaling pathway", PLOS ONE, vol. 9, no. 9, 2014, pages 1 - 9, XP055371434
JUNG-EUN KIMA ET AL.: "Lactobacillus helveticus suppresses experimental rheumatoid arthritis by reducing inflammatory T cell responses", JOURNAL OF FUNCTIONAL FOODS, vol. 13, February 2015 (2015-02-01), pages 350 - 362, XP055371439
FUMIHIKO SAKAI ET AL.: "Lactobacillus gasseri SBT2055 induces TGF-beta expression in dendritic cells and activates TLR2 signal to produce IgA in the small intestine", PLOS ONE, vol. 9, no. 8, 2014, pages 1 - 11, XP055371441
JIA YU -CHEN ET AL.: "Effects of Lactobacillus helveticus on Immune Response and Cytokines in Intestinal Mucosa of Mice", FOOD SCIENCE, vol. 31, no. 23, 2010, pages 335 - 9
JUNG-EUN KIMA ET AL.: "Lactobacillus helveticus suppresses experimental rheumatoid arthritis by reducing inflammatory T cell responses", JOURNAL OF FUNCTIONAL FOODS, vol. 13, February 2015 (2015-02-01), pages 350 - 362, XP055371439
FUMIHIKO SAKAI ET AL.: "Lactobacillus gasseri SBT2055 induces TGF-beta expression in dendritic cells and activates TLR2 signal to produce IgA in the small intestine", PLOS ONE, vol. 9, no. 8, 2014, pages 1 - 11, XP055371441
JIA YU -CHEN ET AL.: "Effects of Lactobacillus helveticus on Immune Response and Cytokines in Intestinal Mucosa of Mice", FOOD SCIENCE, vol. 31, no. 23, 2010, pages 335 - 9
Attorney, Agent or Firm:
MOEGI PATENT OFFICE (JP)
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