Title:
ANTIBODY FOR SPECIFICALLY RECOGNIZING AND BINDING ACTIVE-STRUCTURE REIC/DKK-3 PROTEIN, AND MONITORING FOR CANCER TREATMENT IN WHICH SAID ANTI-REIC/DKK-3 ANTIBODY IS USED
Document Type and Number:
WIPO Patent Application WO/2017/057308
Kind Code:
A1
Abstract:
Provided is an anti-REIC antibody with which it is possible to specifically recognize a cancer-related protein REIC/Dkk-3 and to monitor the results of a cancer treatment in which a REIC/Dkk-3 gene or the REIC/Dkk-3 protein is used as a medicine. Also provided is a method for diagnosis in which said antibody is used. A method for detecting cancer in which: the concentration of REIC/Dkk-3 protein in a biological sample collected from a subject is measured using a first antibody, or a functional fragment thereof, that specifically recognizes a REIC/Dkk-3 protein produced by normal cells and having an active structure, but that does not bind REIC/Dkk-3 protein present in large quantities in the blood of a cancer patient without recognizing said REIC/Dkk-3 protein or has low reactivity with REIC/Dkk-3 protein present in large quantities in the blood of a cancer patient; and, when the concentration of REIC/Dkk-3 protein in the biological sample from the subject is lower than the concentration of REIC/Dkk-3 protein in a biological sample from a normal individual, an assessment is made that the subject is affected by precancer or a neoplastic disorder.
Inventors:
KUMON HIROMI (JP)
KINOSHITA RIE (JP)
FUTAMI JUNICHIRO (JP)
KINOSHITA RIE (JP)
FUTAMI JUNICHIRO (JP)
Application Number:
PCT/JP2016/078339
Publication Date:
April 06, 2017
Filing Date:
September 27, 2016
Export Citation:
Assignee:
NAT UNIV CORP OKAYAMA UNIV (JP)
MOMOTARO-GENE INC (JP)
MOMOTARO-GENE INC (JP)
International Classes:
G01N33/574; C07K16/18; C12N5/12; C12N15/02; C12P21/08; G01N33/53
Domestic Patent References:
| WO2012002582A1 | 2012-01-05 | |||
| WO2001038523A1 | 2001-05-31 |
Other References:
ZHANG,K. ET AL.: "Expression pattern of REIC/Dkk-3 in various cell types and the implications of the soluble form in prostatic acinar development", INTERNATIONAL JOURNAL OF ONCOLOGY, vol. 37, no. 6, December 2010 (2010-12-01), pages 1495 - 1501, XP055371446
ABARZUA,F. ET AL.: "An N-terminal 78 amino acid truncation of REIC/Dkk-3 effectively induces apoptosis", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 375, 24 August 2008 (2008-08-24), pages 614 - 618, XP025428462
See also references of EP 3358353A4
ABARZUA,F. ET AL.: "An N-terminal 78 amino acid truncation of REIC/Dkk-3 effectively induces apoptosis", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 375, 24 August 2008 (2008-08-24), pages 614 - 618, XP025428462
See also references of EP 3358353A4
Attorney, Agent or Firm:
HIRAKI Yusuke et al. (JP)
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